{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:52:06Z","timestamp":1791143526292,"version":"4.1.0"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,12,5]]},"abstract":"<jats:p>Lesion of the \u201cvestibular cortex\u201d in the human posterior\n insula leads to a tilted perception of visual vertical but not to\n tilted body posture and loss of lateral balance. However, some stroke\n patients show the reverse pattern. Although their processing of visual\n and vestibular inputs for orientation perception of the visual world is\n undisturbed, they push away actively from the ipsilesional side (the\n side of lesion location), leading to a contraversive tilt of the body\n (tilt toward the side opposite to the lesion) and falling to that side.\n Recently, the origin of contraversive pushing was identified as an\n altered perception of the body's orientation in relation to gravity.\n These patients experience their body as oriented \u201cupright\u201d when\n actually tilted enormously to the ipsilesional side (18\u00b0 on average).\n The findings argued for a separate pathway in humans for sensing body\n orientation in relation to gravity apart from the one projecting to the\n vestibular cortex. The present study aimed at identifying this brain\n area. The infarcted brain regions of 23 consecutively admitted patients\n with severe contraversive pushing were projected onto a template MRI\n scan, which had been normalized to Talairach space. The overlapping\n area of these infarctions centered on the posterolateral thalamus. Our\n finding necessitates reinterpretation of this area as being only a\n \u201crelay structure\u201d of the vestibular pathway on its way from the\n brainstem to the vestibular cortex. The ventral posterior and lateral\n posterior nuclei of the posterolateral thalamus (and probably its\n cortical projections) rather seem to be fundamentally involved in the\n neural representation of a second graviceptive system in humans\n decisive for our control of upright body posture.<\/jats:p>","DOI":"10.1073\/pnas.240279997","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"13931-13936","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":142,"title":["The neural representation of postural control in humans"],"prefix":"10.1073","volume":"97","author":[{"given":"Hans-Otto","family":"Karnath","sequence":"first","affiliation":[{"name":"Departments of Cognitive and General Neurology, University of\r T\u00fcbingen, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Ferber","sequence":"additional","affiliation":[{"name":"Departments of Cognitive and General Neurology, University of\r T\u00fcbingen, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Dichgans","sequence":"additional","affiliation":[{"name":"Departments of Cognitive and General Neurology, University of\r T\u00fcbingen, D-72076 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,11,21]]},"reference":[{"key":"e_1_3_3_1_2","volume-title":"Br. Med. J.","author":"Beevor C E","year":"1909","unstructured":"C E Beevor Br. Med. J., April 10th, 881\u2013885. (1909)."},{"key":"e_1_3_3_2_2","first-page":"23","volume":"63","author":"Perry J","year":"1969","unstructured":"J Perry Clin Orthop 63, 23\u201331 (1969).","journal-title":"Clin Orthop"},{"key":"e_1_3_3_3_2","volume-title":"Movement Therapy in Hemiplegia: A Neurophysiological Approach","author":"Brunnstrom S","year":"1970","unstructured":"S Brunnstrom Movement Therapy in Hemiplegia: A Neurophysiological Approach (Harper & Row, New York, 1970)."},{"key":"e_1_3_3_4_2","first-page":"43","volume":"10","author":"Bohannon R W","year":"1986","unstructured":"R W Bohannon, A C Cook, P A Larkin, W E Dubuc, M B Smith, M G Horton, C Hypes Neurol Rep 10, 43\u201344 (1986).","journal-title":"Neurol Rep"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-96833-4"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90215-4"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","unstructured":"Karnath H.-O. Ferber S. & Dichgans J. (2000) Neurology 55 in press.","DOI":"10.1212\/WNL.55.9.1298"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410350406"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018306"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018307"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","unstructured":"Karnath H.-O. Br\u00f6tz D. & G\u00f6tz A. (2001) Nervenarzt 72 in press.","DOI":"10.1007\/s001150050719"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91561-4"},{"key":"e_1_3_3_13_2","first-page":"71","volume-title":"Principles of Behavioral Neurology","author":"Weintraub S","year":"1985","unstructured":"S Weintraub, M-M Mesulam Principles of Behavioral Neurology, ed M-M Mesulam (Davis, Philadelphia), pp. 71\u2013124 (1985)."},{"key":"e_1_3_3_14_2","volume-title":"Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System\u2014An Approach to Cerebral Imaging","author":"Talairach J","year":"1988","unstructured":"J Talairach, P Tournoux Co-Planar Stereotaxic Atlas of the Human Brain: 3-Dimensional Proportional System\u2014An Approach to Cerebral Imaging (Thieme, New York, 1988)."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25204.x"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(97)00032-8"},{"key":"e_1_3_3_17_2","first-page":"365","volume":"18","author":"Mittelstaedt H","year":"1964","unstructured":"H Mittelstaedt Symp Soc Exp Biol 18, 365\u2013385 (1964).","journal-title":"Symp Soc Exp Biol"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00696890"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00696891"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002219900238"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230612"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.9.1732"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1968.tb07446.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410310409"},{"key":"e_1_3_3_25_2","first-page":"88","volume":"20","author":"Deeke L","year":"1974","unstructured":"L Deeke, D W F Schwarz, J M Fredrickson Exp Brain Res 20, 88\u2013100 (1974).","journal-title":"Exp Brain Res"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(76)90692-2"},{"key":"e_1_3_3_27_2","volume-title":"Atlas for Stereotaxy of the Human Brain: Architectonic Organisation of the Thalamic Nuclei by Rolf Hassler","author":"Schaltenbrand G","year":"1977","unstructured":"G Schaltenbrand, W Wahren Atlas for Stereotaxy of the Human Brain: Architectonic Organisation of the Thalamic Nuclei by Rolf Hassler (Thieme, Stuttgart, 1977)."},{"key":"e_1_3_3_28_2","volume-title":"The Thalamus and Midbrain of Man: A Physiological Atlas Using Electrical Stimulation","author":"Tasker R R","year":"1982","unstructured":"R R Tasker, L W Organ, P A Hawrylyshyn The Thalamus and Midbrain of Man: A Physiological Atlas Using Electrical Stimulation (Thomas, Springfield, 1982)."},{"key":"e_1_3_3_29_2","first-page":"252","volume":"98","author":"Engelborghs S","year":"1998","unstructured":"S Engelborghs, P Marien, J-J Martin, P P De Deyn Acta Neurol Belg 98, 252\u2013265 (1998).","journal-title":"Acta Neurol Belg"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.5.817"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1749-8"}],"updated-by":[{"DOI":"10.1073\/pnas.98.2.777-e","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2001,1,9]],"date-time":"2001-01-09T00:00:00Z","timestamp":978998400000}}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.240279997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T09:24:14Z","timestamp":1649841854000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.240279997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11,21]]},"references-count":31,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2000,12,5]]}},"alternative-id":["10.1073\/pnas.240279997"],"URL":"https:\/\/doi.org\/10.1073\/pnas.240279997","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11,21]]},"assertion":[{"value":"2000-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}