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In patients with inherited IFNAR1, IFNAR2, TYK2, or IRF9 deficiency, IP-10 is induced only by IFN-\u03b3, whereas, in those with auto-Abs neutralizing specific type I IFNs, IP-10 is also induced by the type I IFNs not neutralized by the auto-Abs. The measurement of type I and type II IFN-dependent IP-10 induction therefore constitutes a simple procedure for detecting rare inborn errors of the type I IFN response pathway and more common auto-Abs neutralizing type I IFNs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2402983121","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T15:02:08Z","timestamp":1727103728000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["A sensitive assay for measuring whole-blood responses to type I IFNs"],"prefix":"10.1073","volume":"121","author":[{"given":"Adrian","family":"Gervais","sequence":"first","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1163, Necker Hospital for Sick Children, Paris 75015, France"},{"name":"Paris Cit\u00e9 University, Imagine Institute, Paris 75015, 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