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Furthermore, we find that antibodies use induced oligomerization both as a primary inhibition mechanism and to enhance the effects of receptor-site blocking. Our results suggest that naive affinity measurements are poor predictors of potency, and introduce an antibody-based inhibition mechanism for oligomeric targets. More generally, they point toward a much broader role of induced oligomerization in controlling biomolecular interactions.<\/jats:p>","DOI":"10.1073\/pnas.2403260121","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T16:54:16Z","timestamp":1727888056000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["Oligomerization-driven avidity correlates with SARS-CoV-2 cellular binding and inhibition"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-4378","authenticated-orcid":false,"given":"Roi","family":"Asor","sequence":"first","affiliation":[{"name":"Physical and Theoretical Chemistry, Department of Chemistry, University of Oxford","place":["Oxford, United Kingdom"]},{"name":"The Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford","place":["Oxford, United 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