{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:02:18Z","timestamp":1792587738654,"version":"4.5.0"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"42","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["InnoHK initiative"],"award-info":[{"award-number":["InnoHK initiative"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:p>\n                    The analysis of tissues of origin of cell-free DNA (cfDNA) is of research and diagnostic interest. Many studies focused on bisulfite treatment or immunoprecipitation protocols to assess the tissues of origin of cfDNA. DNA loss often occurs during such processes. Fragmentomics of cfDNA molecules has uncovered a wealth of information related to tissues of origin of cfDNA. There is still much room for the development of tools for assessing contributions from various tissues into plasma using fragmentomic features. Hence, we developed an approach to analyze the relative contributions of DNA from different tissues into plasma, by identifying characteristic fragmentation patterns associated with selected histone modifications. We named this technique as FRAGmentomics-based Histone modification Analysis (FRAGHA). Deduced placenta-specific histone H3 lysine 27 acetylation (H3K27ac)-associated signal correlated well with the fetal DNA fraction in maternal plasma (Pearson\u2019s\n                    <jats:italic>r<\/jats:italic>\n                    = 0.96). The deduced liver-specific H3K27ac-associated signal correlated with the donor-derived DNA fraction in liver transplantation recipients (Pearson\u2019s\n                    <jats:italic>r<\/jats:italic>\n                    = 0.92) and was significantly increased in patients with hepatocellular carcinoma (HCC) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01, Wilcoxon rank-sum test). Significant elevations of erythroblasts-specific and colon-specific H3K27ac-associated signals were observed in patients with \u03b2-thalassemia major and colorectal cancer, respectively. Furthermore, using the fragmentation patterns from tissue-specific H3K27ac regions, a machine learning algorithm was developed to enhance HCC detection, with an area under the curve (AUC) of up to 0.97. Finally, genomic regions with H3K27ac or histone H3 lysine 4 trimethylation (H3K4me3) were found to exhibit different fragmentomic patterns of cfDNA. This study has shed light on the relationship between cfDNA fragmentomics and histone modifications, thus expanding the armamentarium of liquid biopsy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2404058121","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T12:06:01Z","timestamp":1728475561000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":45,"title":["Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns"],"prefix":"10.1073","volume":"121","author":[{"given":"Jinyue","family":"Bai","sequence":"first","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4523-3476","authenticated-orcid":false,"given":"Peiyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-5706","authenticated-orcid":false,"given":"Lu","family":"Ji","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. K. Jacky","family":"Lam","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-9643","authenticated-orcid":false,"given":"Qing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Jane L.","family":"Ma","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer C.","family":"Ding","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Ramakrishnan","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Wai","family":"Wan","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongxin Claire","family":"Yang","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Yukawa","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca W. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie C. Y.","family":"Yu","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Y. Lois","family":"Choy","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Shi","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommy H. C.","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Fai","family":"Law","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9011-4268","authenticated-orcid":false,"given":"Raymond S. M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-8596","authenticated-orcid":false,"given":"John","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-5480","authenticated-orcid":false,"given":"Stephen Lam","family":"Chan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace L. H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W. S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C. Allen","family":"Chan","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8746-0293","authenticated-orcid":false,"given":"Y. M. Dennis","family":"Lo","sequence":"additional","affiliation":[{"name":"Centre for Novostics, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"},{"name":"State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw3616"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107830"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2019.1598759"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001720"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1500076112"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-0622"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2209852119"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2220982120"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1804134115"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814616115"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvac050"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.261396.120"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.169318"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat4921"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1421126111"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-00775-6"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13394"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02605-z"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-022-01222-4"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3648"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.2217\/epi.13.13"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2540"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.594325"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022112012"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.124"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.265702"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.290304"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508736112"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07466-6"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.272401"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3493"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/35004599"},{"key":"e_1_3_4_33_2","first-page":"588","article-title":"Evaluation of nucleated red blood cell count by Sysmex XE-2100 in patients with thalassaemia or sickle cell anaemia and in neonates","volume":"13","author":"Buoro S.","year":"2015","unstructured":"S. Buoro , Evaluation of nucleated red blood cell count by Sysmex XE-2100 in patients with thalassaemia or sickle cell anaemia and in neonates. Blood Transfus. 13, 588\u2013594 (2015).","journal-title":"Blood Transfus."},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.11.009"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.242719.118"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15219"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2008-9-9-r137"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12714-4"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.64356"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.3.421"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr016"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/19491034.2022.2160551"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-019-0272-y"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.050"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10002"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(00)00096-X"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh4819"},{"key":"e_1_3_4_48_2","unstructured":"J. Bai Histone modifications of cfDNA. European Genome-Phenome Archive (EGA). https:\/\/ega-archive.org\/dacs\/EGAC00001002815. Deposited 22 August 2022."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2404058121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T12:06:19Z","timestamp":1728475579000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2404058121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":48,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2024,10,15]]}},"alternative-id":["10.1073\/pnas.2404058121"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2404058121","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"2024-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2404058121"}}