{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:05:47Z","timestamp":1791453947033,"version":"4.3.3"},"reference-count":139,"publisher":"National Academy of Sciences","issue":"39","license":[{"start":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T00:00:00Z","timestamp":1726444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,9,24]]},"abstract":"<jats:p>\n                    Systemic inflammation elicits sickness behaviors and fever by engaging a complex neuronal circuitry that begins in the preoptic area of the hypothalamus. Ectotherms such as teleost fish display sickness behaviors in response to infection or inflammation, seeking warmer temperatures to enhance survival via behavioral fever responses. To date, the hypothalamus is the only brain region implicated in sickness behaviors and behavioral fever in teleosts. Yet, the complexity of neurobehavioral manifestations underlying sickness responses in teleosts suggests engagement of higher processing areas of the brain. Using in vivo models of systemic inflammation in rainbow trout, we find canonical pyrogenic cytokine responses in the hypothalamus whereas in the telencephalon and the optic tectum\n                    <jats:italic>il-1b<\/jats:italic>\n                    and\n                    <jats:italic>tnfa<\/jats:italic>\n                    expression is decoupled from\n                    <jats:italic>il-6<\/jats:italic>\n                    expression. Polyamine metabolism changes, characterized by accumulation of putrescine and decreases in spermine and spermidine, are recorded in the telencephalon but not hypothalamus upon systemic injection of bacteria. While systemic inflammation causes canonical behavioral fever in trout, blockade of bacterial polyamine metabolism prior to injection abrogates behavioral fever, polyamine responses, and telencephalic but not hypothalamic cytokine responses. Combined, our work identifies the telencephalon as a neuronal substrate for brain responses to systemic inflammation in teleosts and uncovers the role of polyamines as critical chemical mediators in sickness behaviors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2404781121","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T15:34:47Z","timestamp":1726500887000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["The telencephalon is a neuronal substrate for systemic inflammatory responses in teleosts via polyamine metabolism"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-622X","authenticated-orcid":false,"given":"Amir","family":"Mani","sequence":"first","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Barreda","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Alberta, Edmonton, Canada"},{"name":"Department of Agricultural, Food &amp; Nutritional Science, University of Alberta, Edmonton, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-6571","authenticated-orcid":false,"given":"Irene","family":"Salinas","sequence":"additional","affiliation":[{"name":"Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,9,16]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.008"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4102-3"},{"key":"e_1_3_4_3_2","first-page":"595","article-title":"The sympathetic nerve\u2014an integrative interface between two supersystems: The brain and the immune system","volume":"52","author":"Elenkov J.","year":"2000","unstructured":"J. Elenkov, R. L. Wilder, G. P. Chrousos, E. S. Vizi, The sympathetic nerve\u2014an integrative interface between two supersystems: The brain and the immune system. Pharmacol. Rev. 52, 595\u2013638 (2000).","journal-title":"Pharmacol. Rev."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2001000300003"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.02.003"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2886-4"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav4111"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.03.022"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3159"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2023.100703"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(96)00575-6"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04793-z"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64074-1.00034-3"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.028"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.013"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2007.03.005"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44836-9"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577367"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02851-5"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0240-16.2016"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.760882"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.07.004"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.225847"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/657609"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4565(00)00026-7"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/19.1.295"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00444-7"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/267043a0"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.03.023"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.01.010"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.09.008"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83644"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168860"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2016.06.027"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-19-4324-9_15"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1159\/000351994"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-18-07381.1998"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4930-03.2004"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.06.010"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.02.031"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2017.01.002"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00682-7"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02240"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.2266"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00608"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abe0531"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2008.12.004"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.10.061"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0434-1"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.768108"},{"key":"e_1_3_4_52_2","first-page":"177","volume-title":"Vascular Hyperpermeability: Methods and Protocols","author":"Waithe O. Y.","year":"2023","unstructured":"O. Y. Waithe, X. Peng, E. W. Childs, B. Tharakan, \"Measurement of blood-brain barrier hyperpermeability using Evans blue extravasation assay\" in Vascular Hyperpermeability: Methods and Protocols (Springer, 2023), pp. 177\u2013184."},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep06588"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077548"},{"key":"e_1_3_4_55_2","unstructured":"A. Mani A brain microbiome in salmonids at homeostasis. Sci. Adv. in press."},{"key":"e_1_3_4_56_2","doi-asserted-by":"crossref","unstructured":"Y. Ding Secretory IgM (sIgM) is an ancient master regulator of microbiota homeostasis and metabolism. bioRxiv [Preprint] (2023) https:\/\/doi.org\/10.1101\/2023.02.26.530119.","DOI":"10.1101\/2023.02.26.530119"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.734780"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199417000120"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000852"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01373-0"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-017-2370-y"},{"key":"e_1_3_4_62_2","unstructured":"J. Michael Polyamines: A Universal Molecular Nexus for Growth Survival and Specialized Metabolism (Springer Tokyo 2015)."},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.06.020"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvj020"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-481835-4.50016-8"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200301097"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-019-02719-0"},{"key":"e_1_3_4_68_2","first-page":"22","article-title":"Role of polyamines in immune cell functions","volume":"6","author":"Hesterberg R. S.","year":"2018","unstructured":"R. S. Hesterberg, J. L. Cleveland, P. K. Epling-Burnette, Role of polyamines in immune cell functions. Med. Sci. 6, 22 (2018).","journal-title":"Med. Sci."},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(88)80004-6"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(05)80038-7"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.09.006"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.2.8344205"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2013.1381"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/259041a0"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4679"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.01.034"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488856"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(00)00269-9"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb08310.x"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.4.1496-1499.1993"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830221023"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00410-9"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68020704.x"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.05.027"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.04.003"},{"key":"e_1_3_4_86_2","article-title":"The remarkable complexity of the brain microbiome in health and disease","author":"Hu Z.","year":"2023","unstructured":"Z. Hu, C.-A. McKenzie, C. Smith, J. G. Haas, R. Lathe, The remarkable complexity of the brain microbiome in health and disease. bioRxiv [Preprint] (2023), https:\/\/doi.org\/10.1101\/2023.02.06.527297.","journal-title":"bioRxiv [Preprint]"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054673"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4065"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00159"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.10183"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.226357"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1007\/82_2012_297"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-4-431-53933-9_5"},{"key":"e_1_3_4_94_2","first-page":"213","article-title":"Neurogenesis in adult vertebrate spinal cord in situ and in vitro: A new model system","volume":"235","author":"Anderson M. J.","year":"2003","unstructured":"M. J. Anderson, S. G. Waxman, Neurogenesis in adult vertebrate spinal cord in situ and in vitro: A new model system. Form Funct. Brain Spinal Cord 235, 213\u2013233 (2003).","journal-title":"Form Funct. Brain Spinal Cord"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2004.01.001"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.06.008"},{"key":"e_1_3_4_97_2","first-page":"28","article-title":"Polyamine homeostasis in development and disease","volume":"9","author":"Nakanishi S.","year":"2021","unstructured":"S. Nakanishi, J. L. Cleveland, Polyamine homeostasis in development and disease. Med. Sci. 9, 28 (2021).","journal-title":"Med. Sci."},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(86)90236-4"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-009-0184-2"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/0736-5748(86)90061-4"},{"key":"e_1_3_4_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.01.073"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1996.13.487"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1556\/2060.2022.00138"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01558.x"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.10.1759"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405201002"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4781(91)90100-Z"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14020178"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1993.265.2.G331"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002219900254"},{"key":"e_1_3_4_111_2","first-page":"22","article-title":"Role of polyamines in immune cell functions","volume":"6","author":"Hesterberg R. S.","year":"2018","unstructured":"R. S. Hesterberg, J. L. Cleveland, P. K. Epling-Burnette, Role of polyamines in immune cell functions. Med. Sci. 6, 22\u201322 (2018).","journal-title":"Med. Sci."},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90124-5"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.4161\/chan.19001"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16629-3"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01651-w"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyac011"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S262024"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1985.tb05087.x"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90422-4"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.04.035"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.1076223"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.12.013"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.79-94.2002"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/22.4.403"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01577331"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2023.102492"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10295-008-0393-y"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2018.11.003"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-017-0267-5"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.1002\/mbo3.977"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1219"},{"key":"e_1_3_4_136_2","unstructured":"J. E. Bisanz qiime2R: Importing QIIME2 Artifacts and Associated Data into R Sessions. Github. https:\/\/github.com\/jbisanz\/qiime2R. Accessed 27 March 2024."},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036149"},{"key":"e_1_3_4_139_2","unstructured":"A. Mani F. Haddad D. R. Barreda I. Salinas PRJNA1079394 Dysbiotic brain microbiota facilitates rainbow trout telencephalon in detecting systemic inflammatory responses. National Center for Biotechnology Information. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA1079394. Deposited 22 February 2022."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2404781121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T15:36:00Z","timestamp":1726500960000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2404781121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,16]]},"references-count":139,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2024,9,24]]}},"alternative-id":["10.1073\/pnas.2404781121"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2404781121","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,16]]},"assertion":[{"value":"2024-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2404781121"}}