{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:59:08Z","timestamp":1792641548212,"version":"4.5.0"},"reference-count":72,"publisher":"National Academy of Sciences","issue":"41","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000061","name":"HHS | NIH | Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW012274"],"award-info":[{"award-number":["D43TW012274"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI141681-04"],"award-info":[{"award-number":["AI141681-04"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI70774-01A1"],"award-info":[{"award-number":["1R01AI70774-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"HHS | NIH | NIAID | Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI137527"],"award-info":[{"award-number":["R01AI137527"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017540","name":"HHS | NIH | NHLBI | Division of Intramural Research","doi-asserted-by":"publisher","award":["U01GH00227847"],"award-info":[{"award-number":["U01GH00227847"]}],"id":[{"id":"10.13039\/100017540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010208","name":"DOD | OSD | Defense Technical Information Center","doi-asserted-by":"publisher","award":["W81XWH1910026"],"award-info":[{"award-number":["W81XWH1910026"]}],"id":[{"id":"10.13039\/100010208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"HHS | NIH | NIAID | Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AG078268"],"award-info":[{"award-number":["R01AG078268"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"HHS | NIH | NIAID | Division of Intramural Research","doi-asserted-by":"publisher","award":["R01AI165721"],"award-info":[{"award-number":["R01AI165721"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006221","name":"Cordis","doi-asserted-by":"publisher","award":["101007873"],"award-info":[{"award-number":["101007873"]}],"id":[{"id":"10.13039\/501100006221","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001713","name":"EC | H2020 | ERA-LEARN | European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["RIA2018CO-2514"],"award-info":[{"award-number":["RIA2018CO-2514"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210227"],"award-info":[{"award-number":["RP210227"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008746","name":"National Cancer Center","doi-asserted-by":"publisher","award":["P30CA125123"],"award-info":[{"award-number":["P30CA125123"]}],"id":[{"id":"10.13039\/100008746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P30ES030285 1P42ES0327725"],"award-info":[{"award-number":["P30ES030285 1P42ES0327725"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006545","name":"HHS | NIH | National Institute on Minority Health and Health Disparities","doi-asserted-by":"publisher","award":["P50MD015496"],"award-info":[{"award-number":["P50MD015496"]}],"id":[{"id":"10.13039\/100006545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AG078268-01A1"],"award-info":[{"award-number":["1R01AG078268-01A1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1127276-2015"],"award-info":[{"award-number":["OPP1127276-2015"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>\n                    Severe and chronic infections, including pneumonia, sepsis, and tuberculosis (TB), induce long-lasting epigenetic changes that are associated with an increase in all-cause postinfectious morbidity and mortality. Oncology studies identified metabolic drivers of the epigenetic landscape, with the tricarboxylic acid (TCA) cycle acting as a central hub. It is unknown if the TCA cycle also regulates epigenetics, specifically DNA methylation, after infection-induced immune tolerance. The following studies demonstrate that lipopolysaccharide and\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    induce changes in DNA methylation that are mediated by the TCA cycle. Infection-induced DNA hypermethylation is mitigated by inhibitors of cellular metabolism (rapamycin, everolimus, metformin) and the TCA cycle (isocitrate dehydrogenase inhibitors). Conversely, exogenous supplementation with TCA metabolites (succinate and itaconate) induces DNA hypermethylation and immune tolerance. Finally, TB patients who received everolimus have less DNA hypermethylation demonstrating proof of concept that metabolic manipulation can mitigate epigenetic scars.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2404841121","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T15:06:14Z","timestamp":1727708774000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":37,"title":["TCA metabolism regulates DNA hypermethylation in LPS and\n                    <i>Mycobacterium tuberculosis<\/i>\n                    \u2013induced immune tolerance"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7888-8722","authenticated-orcid":false,"family":"Abhimanyu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8731-0105","authenticated-orcid":false,"given":"Santiago Carrero","family":"Longlax","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Nishiguchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-5696","authenticated-orcid":false,"given":"Malik","family":"Ladki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daanish","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amera L.","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0226-7393","authenticated-orcid":false,"given":"Emily M.","family":"Mace","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-3134","authenticated-orcid":false,"given":"Sandra L.","family":"Grimm","sequence":"additional","affiliation":[{"name":"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030"},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaleia","family":"Caldwell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Portillo Varela","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal V.","family":"Sekhar","sequence":"additional","affiliation":[{"name":"Translational Metabolism Unit, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Mandalakas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"},{"name":"Epidemiology, Human Genetics &amp; Environmental Sciences, University of Texas-UTHealth School of Public Health, Houston, TX 77030"},{"name":"Clinical Infectious Disease Group, German Center for Infectious Research (DZIF), Clinical tuberculosis (TB) Unit, Research Center Borstel, Borstel 27246, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-1051","authenticated-orcid":false,"given":"Mandla","family":"Mlotshwa","sequence":"additional","affiliation":[{"name":"The Aurum institute, Johannesburg 2006, South Africa"},{"name":"Department of Biomedical Sciences, Faculty of Health Sciences, University of Johannesburg, Johannesburg 2006, South Africa"},{"name":"Department of Medicine, Vanderbilt University, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibuse","family":"Ginidza","sequence":"additional","affiliation":[{"name":"The Aurum institute, Johannesburg 2006, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3058-2702","authenticated-orcid":false,"given":"Jeffrey D.","family":"Cirillo","sequence":"additional","affiliation":[{"name":"Center for Airborne Pathogen Research and Imaging, Texas A&amp;M College of Medicine, Bryan, TX 77843"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Wallis","sequence":"additional","affiliation":[{"name":"The Aurum institute, Johannesburg 2006, South Africa"},{"name":"Department of Medicine, Case Western Reserve University, Cleveland, OH 44106"},{"name":"Vanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands"},{"name":"Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn 53113, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford OX1 4BH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Coarfa","sequence":"additional","affiliation":[{"name":"Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030"},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"DiNardo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Global TB Program, William T Shearer Center for Immunobiology, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, TX 77030"},{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen 6525, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI134622"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1274-4"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02976"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12268"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00602-06"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97508"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753425919842320"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103044"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i2375"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30309-3"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis1207"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2028358"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00979-1"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6910"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4323"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-106443"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2016.03.003"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.01.006"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620498114"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251086"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00798-16"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.007"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203161"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800101"},{"key":"e_1_3_4_25_2","first-page":"827","article-title":"Cell-mediated immunity in anergic patients with pulmonary tuberculosis","volume":"118","author":"Mcmurray D. N.","year":"1978","unstructured":"D. N. Mcmurray, A. Echeverri, Cell-mediated immunity in anergic patients with pulmonary tuberculosis. Am. Rev. Respir. Dis. 118, 827\u2013834 (1978).","journal-title":"Am. Rev. Respir. Dis."},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.24.13227"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.3.14017"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa5993"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05836"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02550-18"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.04.004"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.07.008"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.165"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.8.6.519"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.034"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25986"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180118"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.09.003"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112658"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.11.015"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20165"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0095-6"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00688-13"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MA0114-034RR"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070630"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-019-0674-2"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.001"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.09.034"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13668-3"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.688132"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0577-9"},{"key":"e_1_3_4_52_2","first-page":"248","volume-title":"Navigating Metabolism","author":"Chandel N. S.","year":"2015","unstructured":"N. S. Chandel, Navigating Metabolism (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2015), p. 248."},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.7171\/jbt.21-3202-001"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00853-8"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.688762"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1515\/znb-1958-0806"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-021-05488-w"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0673-x"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30448-3"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.057"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S65331"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.11.020"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.011"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-9-91"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab964"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003084"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02263-2021"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.11.038"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2022.104596"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203936"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","unstructured":"Abhimanyu TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis\u2013induced immune tolerance. Gene Expression Omnibus. https:\/\/www.ncbi.xyz\/geo\/query\/acc.cgi?acc=GSE276988. Deposited 12 September 2024.","DOI":"10.1073\/pnas.2404841121"},{"key":"e_1_3_4_72_2","doi-asserted-by":"crossref","unstructured":"Abhimanyu TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis\u2013induced immune tolerance. Gene Expression Omnibus. https:\/\/www.ncbi.xyz\/geo\/query\/acc.cgi?acc=GSE277003. Deposited 12 September 2024.","DOI":"10.1073\/pnas.2404841121"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2404841121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T17:36:43Z","timestamp":1732815403000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2404841121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":72,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2024,10,8]]}},"alternative-id":["10.1073\/pnas.2404841121"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2404841121","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"2024-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2404841121"}}