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Investigating the underlying signaling pathways, we found that BARD1 forms a trimeric protein complex with p53 and SERCA2 that regulates calcium signaling and apoptosis. We validated these findings in\n                    <jats:italic>BARD1<\/jats:italic>\n                    -silenced primary human mesothelial cells exposed to asbestos. Our study elucidated mechanisms of\n                    <jats:italic>BARD1<\/jats:italic>\n                    activity and revealed that heterozygous germline\n                    <jats:italic>BARD1<\/jats:italic>\n                    mutations favor the development of mesothelioma and increase the susceptibility to asbestos carcinogenesis. These mesotheliomas are significantly less aggressive compared to mesotheliomas in asbestos workers.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2405231121","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T13:50:29Z","timestamp":1720705829000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["Germline\n                    <i>BARD1<\/i>\n                    variants predispose to mesothelioma by impairing DNA repair and calcium signaling"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-7478","authenticated-orcid":false,"given":"Flavia","family":"Novelli","sequence":"first","affiliation":[{"name":"Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI 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