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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,9,24]]},"abstract":"<jats:p>\n                    The opportunistic pathogen\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    , carries variants of\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    resistance islands (AbaR)-type genomic islands conferring multidrug resistance. Their pervasiveness in the species has remained enigmatic. The dissemination of AbaRs is intricately linked to their horizontal transfer via natural transformation, a process through which bacteria can import and recombine exogenous DNA, effecting allelic recombination, genetic acquisition, and deletion. In experimental populations of the closely related pathogenic\n                    <jats:italic>Acinetobacter nosocomialis<\/jats:italic>\n                    , we quantified the rates at which these natural transformation events occur between individuals. When integrated into a model of population dynamics, they lead to the swift removal of AbaRs from the population, contrasting with the high prevalence of AbaRs in genomes. Yet, genomic analyses show that nearly all AbaRs specifically disrupt\n                    <jats:italic>comM<\/jats:italic>\n                    , a gene encoding a helicase critical for natural transformation. We found that such disruption impedes gene acquisition, and deletion, while moderately impacting acquisition of single nucleotide polymorphism. A mathematical evolutionary model demonstrates that AbaRs inserted into\n                    <jats:italic>comM<\/jats:italic>\n                    gain a selective advantage over AbaRs inserted in sites that do not inhibit or completely inhibit transformation, in line with the genomic observations. The persistence of AbaRs can be ascribed to their integration into a specific gene, diminishing the likelihood of their removal from the bacterial genome. This integration preserves the acquisition and elimination of alleles, enabling the host bacterium\u2014and thus its AbaR\u2014to adapt to unpredictable environments and persist over the long term. This work underscores how manipulation of natural transformation by mobile genetic elements can drive the prevalence of multidrug resistance.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2409843121","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T13:40:03Z","timestamp":1726580403000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6097-2210","authenticated-orcid":false,"given":"R\u00e9mi","family":"Tuffet","sequence":"first","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, Univ Lyon, Lyon 69007, France"},{"name":"UMR CNRS 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne 69100, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6864-5815","authenticated-orcid":false,"given":"Gabriel","family":"Carvalho","sequence":"additional","affiliation":[{"name":"UMR CNRS 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne 69100, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Godeux","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, Univ Lyon, Lyon 69007, France"},{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Marcy l'Etoile 69280, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2746-4901","authenticated-orcid":false,"given":"Fanny","family":"Mazzamurro","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3525, Microbial Evolutionary Genomics, Paris 75015, France"},{"name":"Coll\u00e8ge Doctoral, Sorbonne Universit\u00e9, Paris F-75005, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-822X","authenticated-orcid":false,"given":"Eduardo P. C.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, CNRS UMR3525, Microbial Evolutionary Genomics, Paris 75015, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5796-5995","authenticated-orcid":false,"given":"Maria-Halima","family":"Laaberki","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, Univ Lyon, Lyon 69007, France"},{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Marcy l'Etoile 69280, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-3733","authenticated-orcid":false,"given":"Samuel","family":"Venner","sequence":"additional","affiliation":[{"name":"UMR CNRS 5558, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne 69100, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-8021","authenticated-orcid":false,"given":"Xavier","family":"Charpentier","sequence":"additional","affiliation":[{"name":"Centre International de Recherche en Infectiologie, Inserm, U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS, UMR5308, \u00c9cole Normale Sup\u00e9rieure de Lyon, Univ Lyon, Lyon 69007, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1080\/22221751.2019.1698273","article-title":"The incidence and prevalence of hospital-acquired (carbapenem-resistant) Acinetobacter baumannii in Europe, Eastern Mediterranean and Africa: A systematic review and meta-analysis","volume":"8","author":"Ayobami O.","year":"2019","unstructured":"O. 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