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Subsequent characterization of the transcriptional and epigenetic landscape of fms-like tyrosine kinase 3\n                    <jats:sup>+<\/jats:sup>\n                    (Flt3\n                    <jats:sup>+<\/jats:sup>\n                    ) DC progenitors and follow-up studies revealed increased apoptosis and reduced proliferation in different individual DC-progenitors as well as a profound type I interferon (IFN-I)-dependent ablation of pre-pDCs, but not pre-DC precursors, after both acute and chronic LCMV infections. In addition, integrated genomic analysis identified altered activity of 34 transcription factors in Flt3\n                    <jats:sup>+<\/jats:sup>\n                    DC progenitors from infected mice, including two regulators of Glucocorticoid (GC) responses. Subsequent studies demonstrated that addition of GCs to DC progenitors led to downregulated pDC-primed-genes while upregulating cDC-primed-genes, and that endogenous GCs selectively decreased pDC, but not cDC, numbers upon in vivo LCMV infection. These findings demonstrate a significant ablation of pre-pDCs in infected mice and identify GCs as suppressors of pDC generation from early progenitors. This provides a potential explanation for the impaired pDC development following viral infection and links pDC numbers to the hypothalamic\u2013pituitary\u2013adrenal axis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2410092122","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T15:00:36Z","timestamp":1745852436000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Genomic analysis of progenitors in viral infection implicates glucocorticoids as suppressors of plasmacytoid dendritic cell generation"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1340-1968","authenticated-orcid":false,"given":"Yeara","family":"Jo","sequence":"first","affiliation":[{"name":"Division of Biological Sciences, University of California, San Diego","place":["La Jolla"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trever 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