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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,12,3]]},"abstract":"<jats:p>\n                    Autophagy is a key innate immune defense mechanism in intestinal epithelial cells. Bacterial invasion of epithelial cells activates antibacterial autophagy through a process that requires the innate immune adaptor protein MYD88, yet how MYD88 signaling connects to the autophagy machinery is unknown. Here, we show that the mouse intestinal pathogen\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    enterica Serovar Typhimurium (\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    Typhimurium) triggers MYD88 signaling that regulates binding of the anti-autophagy factor B cell lymphoma 2 (BCL2) to the essential autophagy protein Beclin1 (BECN1) in small intestinal enterocytes, a key epithelial cell lineage.\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    infection activated the kinase c-Jun N-terminal protein kinase 1 (JNK1) downstream of MYD88. JNK1 induced enterocyte BCL2 phosphorylation, promoting dissociation of the inhibitory BCL2\u2013BECN1 complex and releasing BECN1 to initiate autophagy. Mice with BCL2 phosphorylation site mutations that prevent BCL2\u2013BECN1 dissociation showed increased\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    invasion of enterocytes and dissemination to extraintestinal sites. These findings reveal that BCL2 links MYD88 signaling to enterocyte autophagy initiation, providing mechanistic insight into how invading bacteria trigger autophagy in the intestinal epithelium.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2410205121","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T12:13:52Z","timestamp":1732709632000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["BCL2 regulates antibacterial autophagy in the intestinal epithelium"],"prefix":"10.1073","volume":"121","author":[{"given":"Yun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Immunology, University of Texas Southwestern Medical 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