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Here, however, we demonstrate that LT also enhances the expression of CEACAMs on extracellular vesicles (EV) shed by intestinal epithelia and that CEACAM-laden EV increase in abundance during human infections, mitigate pathogen\u2013host interactions, scavenge free ETEC toxins, and accelerate ETEC clearance from the gastrointestinal tract. Collectively, these findings indicate that CEACAMs play a multifaceted role in ETEC pathogen\u2013host interactions, transiently favoring the pathogen, but ultimately contributing to innate responses that extinguish these common infections.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2410679121","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:03:56Z","timestamp":1726142636000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["Host-derived CEACAM-laden vesicles engage enterotoxigenic\n                    <i>Escherichia coli<\/i>\n                    for elimination and toxin neutralization"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-6978","authenticated-orcid":false,"given":"Alaullah","family":"Sheikh","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University in Saint Louis, School of Medicine, Saint Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1899-1953","authenticated-orcid":false,"given":"Debayan","family":"Ganguli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University in Saint Louis, School of Medicine, Saint Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Vickers","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University in Saint Louis, School of Medicine, Saint Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2213-6000","authenticated-orcid":false,"given":"Bernhard B.","family":"Singer","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-5625","authenticated-orcid":false,"given":"Jennifer","family":"Foulke-Abel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjahan","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Washington University in Saint Louis, School of Medicine, Saint Louis, MO 63110"},{"name":"Enteric and Respiratory. 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