{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:02:37Z","timestamp":1792526557167,"version":"4.5.0"},"reference-count":51,"publisher":"National Academy of Sciences","issue":"38","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"HHMI","doi-asserted-by":"publisher","award":["Chen"],"award-info":[{"award-number":["Chen"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,9,17]]},"abstract":"<jats:p>\n                    Detection of cytosolic DNA by the cyclic GMP-AMP (cGAMP) synthase (cGAS)\u2013stimulator of interferon genes (STING) pathway provides immune defense against pathogens and cancer but can also cause autoimmunity when overactivated. The exonuclease three prime repair exonuclease 1 (TREX1) degrades DNA in the cytosol and prevents cGAS activation by self-DNA. Loss-of-function mutations of the TREX1 gene are linked to autoimmune diseases such as Aicardi\u2013Gouti\u00e8res syndrome, and mice deficient in TREX1 develop lethal inflammation in a cGAS-dependent manner. In order to determine the type of cells in which cGAS activation drives autoinflammation, we generated conditional cGAS knockout mice on the Trex1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    background. Here, we show that genetic ablation of the cGAS gene in classical dendritic cells (cDCs), but not in macrophages, was sufficient to rescue Trex1\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice from all observed disease phenotypes including lethality, T cell activation, tissue inflammation, and production of antinuclear antibodies and interferon-stimulated genes. These results show that cGAS activation in cDC causes autoinflammation in response to self-DNA accumulated in the absence of TREX1.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2411747121","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T11:35:51Z","timestamp":1725968151000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice"],"prefix":"10.1073","volume":"121","author":[{"given":"Tong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, 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