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Mucus conditions, in particular, are important biomarkers for indicating inflammation and stent patency but remain challenging to monitor. Current methods, reliant on computational tomography imaging and bronchoscope inspection, pose risks due to radiation and lack the ability to provide continuous real-time feedback outside of hospitals. Inspired by the sensing ability of biological cilia, we report wireless sensing mechanisms in sensory artificial cilia for detecting mucus conditions, including viscosity and layer thickness, which are crucial biomarkers for disease severity. The sensing mechanism for mucus viscosity leverages external magnetic fields to actuate a magnetic artificial cilium and sense its shape using a flexible strain-gauge. Additionally, we report an artificial cilium with capacitance sensing for mucus layer thickness, offering unique self-calibration, adjustable sensitivity, and range, all enabled by external magnetic fields. To enable prolonged and wireless data access, we integrate Bluetooth Low Energy communication and onboard power, along with a wearable magnetic actuation system for sensor activation. We validate our method by deploying the sensor independently or in conjunction with an airway stent within a trachea phantom and sheep trachea ex vivo. The proposed sensing mechanisms and devices pave the way for real-time monitoring of mucus conditions, facilitating early disease detection and providing stent patency alerts, thereby allowing timely interventions and personalized care.<\/jats:p>","DOI":"10.1073\/pnas.2412086121","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T10:21:24Z","timestamp":1730974884000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Sensory artificial cilia for in situ monitoring of airway physiological properties"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-4942","authenticated-orcid":false,"given":"Yusheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9221-5160","authenticated-orcid":false,"given":"Carlos","family":"Negron","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alend","family":"Khoshnaw","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4711-1871","authenticated-orcid":false,"given":"Steven","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hieu","family":"Vu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Quatela","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Division of Allergy, Pulmonary and Critical Care Medicine, School of Medicine, Vanderbilt University, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6948-1103","authenticated-orcid":false,"given":"Caitlin","family":"Demarest","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4510-1860","authenticated-orcid":false,"given":"Caglar","family":"Oskay","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Department of Civil and Environmental Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9150-4014","authenticated-orcid":false,"given":"Xiaoguang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Vanderbilt Institute for Surgery and Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37212"},{"name":"Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37212"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","unstructured":"E. 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