{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:59:54Z","timestamp":1781103594004,"version":"3.54.1"},"reference-count":67,"publisher":"National Academy of Sciences","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-20-CE02-0015"],"award-info":[{"award-number":["ANR-20-CE02-0015"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agence National de la Recherche","award":["SEXYMUS ANR-10-JCJC-1605"],"award-info":[{"award-number":["SEXYMUS ANR-10-JCJC-1605"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["SEXREV ANR-18\u2010CE02\u20100018\u201001"],"award-info":[{"award-number":["SEXREV ANR-18\u2010CE02\u20100018\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,1,7]]},"abstract":"<jats:p>\n                    A wave of studies has recently emphasized the influence of sex chromosomes on both lifespan and actuarial senescence patterns across vertebrates and invertebrates. Basically, the heterogametic sex (XY males in XX\/XY systems or ZW females in ZW\/ZZ systems) typically displays a lower lifespan and a steeper rate of actuarial senescence than the homogametic sex. However, whether these effects extend to the senescence patterns of other phenotypic traits or physiological functions is yet to be determined. Here, we investigated whether sex chromosomes modulate reproductive senescence using females from the African pygmy mouse (\n                    <jats:italic>Mus minutoides<\/jats:italic>\n                    ). This biological model exhibits an odd sex determining system with a third, feminizing sex chromosome, X*, resulting in three distinct female genotypes (XX, X*X, or X*Y) that coexist in natural populations. We found that the rate of senescence in litter size at birth is much more pronounced in heterogametic X*Y females than in homogametic XX or X*X females that may support the unguarded X or toxic Y hypotheses and can be directly linked to the complex and unique X*Y phenotype. A decrease in neonatal survival with mother\u2019s age has also been found, but this decline is not different between the three female genotypes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2412609121","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T13:42:02Z","timestamp":1735652522000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["X*Y females exhibit steeper reproductive senescence in the African pygmy mouse"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9898-2353","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Lema\u00eetre","sequence":"first","affiliation":[{"name":"Universite Lyon 1, CNRS, Laboratoire de Biom\u00e9trie et Biologie \u00c9volutive, UMR 5558","place":["Villeurbanne, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0572-7199","authenticated-orcid":false,"given":"Yann","family":"Voituron","sequence":"additional","affiliation":[{"name":"Universite Claude Bernard Lyon 1, CNRS, Ecole de l\u2019am\u00e9nagement durable des territoires (ENTPE), Laboratoire d\u2019Ecologie des Hydrosyst\u00e8mes Naturels et Anthropis\u00e9s (LEHNA), UMR 5023","place":["Villeurbanne, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7977-1104","authenticated-orcid":false,"given":"L\u00e9a","family":"Herpe","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chimie et Biochimie, Universit\u00e9 de Moncton","place":["Moncton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1706-9915","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Veyrunes","sequence":"additional","affiliation":[{"name":"Institut des Sciences de l\u2019Evolution de Montpellier","place":["UMR 5554 (CNRS, Universit\u00e9 Montpellier, Institut de recherche pour le d\u00e9veloppement), Montpellier, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.07.004"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111377"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311857110"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2023.1349845"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/663194"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2015.08.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.680471"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2019.0615"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-018-0181-y"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13542"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","unstructured":"J.-F. Lemaitre \u201cSex dIfferences in Longevity Ageing and Health. What Can We Learn from Evolutionary Biology?\u201d in The Biodemography of Ageing and Longevity J.F. Lema\u00eetre S. Pavard Eds. (Cambridge University Press 2024).","DOI":"10.1017\/9781009007245"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2019.0867"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/evo.14410"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/394411"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-020-1179-5"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15380"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063022"},{"key":"e_1_3_4_18_2","volume-title":"The Differences between The Sexes","author":"Fredga K.","year":"1994","unstructured":"K. Fredga, \u201cBizarrre Mammalian Sex-Determining Mechanisms\u201d in The Differences between The Sexes, R.V. Short, E. 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Bates , Package \u2018lme4\u2019. Version 1, 17 (2018).","journal-title":"Package \u2018lme4\u2019. Version"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2023.1139235"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2008.0925"},{"key":"e_1_3_4_63_2","volume-title":"Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach","author":"Burnham K. P.","year":"2003","unstructured":"K. P. Burnham, D. R. Anderson, Model Selection and Multimodel Inference: A Practical Information-Theoretic Approach (Springer Science & Business Media, 2003)."},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2435.2008.01408.x"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1086\/503331"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0587.2012.07348.x"},{"key":"e_1_3_4_67_2","unstructured":"J. F. Lema\u00eetre Females exhibit steeper reproductive senescence in African pygmy mouse. Zenodo. https:\/\/zenodo.org\/records\/13940837. Deposited 16 October 2024."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2412609121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T13:44:09Z","timestamp":1735652649000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2412609121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,7]]}},"alternative-id":["10.1073\/pnas.2412609121"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2412609121","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]},"assertion":[{"value":"2024-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2412609121"}}