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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:p>\n                    Granulomas play a crucial role in the pathology of tuberculosis, but the immune environment governing their formation remains largely unknown. To explore the dynamic changes in the immune microenvironment during the formation of tuberculous granulomas, we infected adult zebrafish with\n                    <jats:italic toggle=\"yes\">Mycobacterium marinum<\/jats:italic>\n                    and then examined uninfected and infected kidneys, as well as large and small granulomas in the kidneys. Using single-cell RNA sequencing technology, we identified two major macrophage subpopulations in the hematopoietic tissue (kidney) of zebrafish under uninfected physiological conditions: monocyte derived and tissue-resident macrophages. Interestingly, the infection induced the emergence of epithelioid cells and a previously undescribed\n                    <jats:italic toggle=\"yes\">grna.2<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    macrophage subpopulation. Depletion of\n                    <jats:italic toggle=\"yes\">grna.2<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    macrophages with the nitroreductase-metronidazole ablation system resulted in shortened zebrafish survival after infection, increased bacterial load, and more granulomas, especially necrotic granulomas. Depletion of\n                    <jats:italic toggle=\"yes\">grna.2<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    macrophages also produced a denser granuloma structure with fewer T cells. RNA-seq and flow cytometry analysis revealed that depletion of\n                    <jats:italic toggle=\"yes\">grna.2<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    macrophages led to upregulated inflammatory signaling pathways, including\n                    <jats:italic toggle=\"yes\">tnf\u03b1<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">il1\u03b2<\/jats:italic>\n                    , and increased macrophage lytic cell death. Similarly, in samples from tuberculosis patients, we also identified GRN-positive macrophages, which exhibit similar anti-inflammatory functions. This subset of\n                    <jats:italic toggle=\"yes\">grna.2<\/jats:italic>\n                    <jats:sup>+<\/jats:sup>\n                    macrophages present in developing granulomas can suppress excessive inflammatory responses to alleviate macrophage lytic death, reduce tissue damage, promote T cell infiltration and ultimately help control mycobacterial growth in vivo.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2413946122","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T17:38:00Z","timestamp":1753810680000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":10,"title":["A granulin-positive macrophage subtype in mycobacterial granulomas alleviates tissue damage by limiting excessive inflammation"],"prefix":"10.1073","volume":"122","author":[{"given":"Geyang","family":"Luo","sequence":"first","affiliation":[{"name":"Center for Tuberculosis Research, Shanghai Public Health 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