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Proteins associated with HPS were enriched in hallmark pathways such as immune response, inflammation, cellular signaling, and metabolic regulation. The external validity was evaluated using the Essential Hypertension Epigenetics study with proteomic data also from the Olink Explore 3072 and complementary epigenetic data, making it a valuable tool for assessing healthspan and as a potential surrogate marker to complement existing proteomic and epigenetic biological age measures in geroscience-guided studies.<\/jats:p>","DOI":"10.1073\/pnas.2414086122","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T13:39:16Z","timestamp":1749217156000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["A proteomic signature of healthspan"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-2380","authenticated-orcid":false,"given":"Chia-Ling","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences, University of Connecticut Health Center","place":["Farmington"]},{"name":"Biostatistics Center, The Cato T. 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