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Notably, conditional depletion of APR2 resulted in significant impairments in motility and invasion. Electron microscopy and cryoelectron tomography revealed that depletion of APR2 alters APR integrity, affecting conoid extrusion and causing cytosolic leakage of F-actin. These findings implicate the APR structure in directing the apico-basal flux of F-actin to regulate parasite motility and invasion.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2416602121","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T11:44:53Z","timestamp":1731066293000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":13,"title":["Architecture of the\n                    <i>Toxoplasma gondii<\/i>\n                    apical polar ring and its role in gliding motility and invasion"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8558-6316","authenticated-orcid":false,"given":"Bingjian","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva 1206, 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