{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:47:44Z","timestamp":1791002864092,"version":"4.1.0"},"reference-count":81,"publisher":"National Academy of Sciences","issue":"9","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019180","name":"EC | ERC | HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["ERC-2016-STG-715182"],"award-info":[{"award-number":["ERC-2016-STG-715182"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 359 - Project number 491676693"],"award-info":[{"award-number":["TRR 359 - Project number 491676693"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1335\/P08 - Project number 360372040"],"award-info":[{"award-number":["SFB 1335\/P08 - Project number 360372040"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FOR2599 (project P03 SCHR 1444\/2-1)"],"award-info":[{"award-number":["FOR2599 (project P03 SCHR 1444\/2-1)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 374\/1 2024 TP B07 (project number 509149993)"],"award-info":[{"award-number":["TRR 374\/1 2024 TP B07 (project number 509149993)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DU548\/6-1 (project number 431402787)"],"award-info":[{"award-number":["DU548\/6-1 (project number 431402787)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1292\/2-TP20 (Project Nr. 318346496)"],"award-info":[{"award-number":["CRC1292\/2-TP20 (Project Nr. 318346496)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR355\/1-A09 (Project Nr. 490846870)"],"award-info":[{"award-number":["TRR355\/1-A09 (Project Nr. 490846870)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,3,4]]},"abstract":"<jats:p>\n                    Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, and comparative cross-species transcriptomics to show that ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs are a conserved, functionally versatile, and transcriptionally distinct type of DCs. ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs entail various populations described in different contexts including Janus cells\/ROR\u03b3t-expressing extrathymic Aire-expressing cells (eTACs), subtypes of Thetis cells, ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    -DC (R-DC) like cells, cDC2C and ACY3\n                    <jats:sup>+<\/jats:sup>\n                    DCs. We show that in response to inflammatory triggers, ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs can migrate to lymph nodes and in the spleen can activate na\u00efve CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These findings expand the functional repertoire of ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs beyond the known role of eTACs and Thetis cells in inducing T cell tolerance to self-antigens and intestinal microbes in mice. We further show that ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs with proinflammatory features accumulate in autoimmune neuroinflammation in mice and men. Thus, our work establishes ROR\u03b3t\n                    <jats:sup>+<\/jats:sup>\n                    DCs as immune sentinel cells that exhibit a broad functional spectrum ranging from inducing peripheral T cell tolerance to T cell activation depending on signals they integrate from their environment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2417308122","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T15:08:51Z","timestamp":1740409731000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":49,"title":["ROR\u03b3t-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells"],"prefix":"10.1073","volume":"122","author":[{"given":"Hamsa","family":"Narasimhan","sequence":"first","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Richter","sequence":"additional","affiliation":[{"name":"Biomedical Center, Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Shakiba","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos E.","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Stehle","sequence":"additional","affiliation":[{"name":"Institute for Medical Immunology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushikk","family":"Ravi Rengarajan","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Ulmert","sequence":"additional","affiliation":[{"name":"Section for Experimental and Translational Immunology, Institute for Health Technology, Technical University of Denmark","place":["Kongens Lyngby, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arek","family":"Kendirli","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Medical Faculty, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Munich Cluster of Systems Neurology (SyNergy)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"de la Rosa","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Medical Faculty, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Graduate School of Systemic Neurosciences, LMU","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Yu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9692-2976","authenticated-orcid":false,"given":"Abigail","family":"Altman","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University","place":["Lund, Sweden"]},{"name":"Wallenberg Centre for Molecular Medicine at Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1289-6833","authenticated-orcid":false,"given":"Philipp","family":"M\u00fcnch","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum f\u00fcr Immuntherapie), University Medical Center Johannes Gutenberg-University Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9029-8784","authenticated-orcid":false,"given":"Saba","family":"Mahboubi","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum f\u00fcr Immuntherapie), University Medical Center Johannes Gutenberg-University Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"K\u00fcntzel","sequence":"additional","affiliation":[{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Sayed","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8277-0663","authenticated-orcid":false,"given":"Eva-Lena","family":"Stange","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University Hospital","place":["Aachen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Pes","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University Hospital","place":["Aachen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Ulezko Antonova","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9724-1382","authenticated-orcid":false,"given":"Carlos-Filipe","family":"Pereira","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Gene Therapy, Lund Stem Cell Centre, Lund University","place":["Lund, Sweden"]},{"name":"Wallenberg Centre for Molecular Medicine at Lund University","place":["Lund, Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludger","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-134X","authenticated-orcid":false,"given":"Diana","family":"Dudziak","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Jena University Hospital of the Friedrich-Schiller-University","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5222-4987","authenticated-orcid":false,"given":"Marco","family":"Colonna","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology, Washington University School of Medicine","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-8724","authenticated-orcid":false,"given":"Natalia","family":"Torow","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University Hospital","place":["Aachen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-9110","authenticated-orcid":false,"given":"Mathias W.","family":"Hornef","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Rheinisch-Westf\u00e4lische Technische Hochschule Aachen University Hospital","place":["Aachen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2484-7842","authenticated-orcid":false,"given":"Bj\u00f6rn E.","family":"Clausen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine and Research Center for Immunotherapy (Forschungszentrum f\u00fcr Immuntherapie), University Medical Center Johannes Gutenberg-University Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kerschensteiner","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Medical Faculty, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Munich Cluster of Systems Neurology (SyNergy)","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Lahl","sequence":"additional","affiliation":[{"name":"Section for Experimental and Translational Immunology, Institute for Health Technology, Technical University of Denmark","place":["Kongens Lyngby, Denmark"]},{"name":"Immunology Section, Lund University","place":["Lund, Sweden"]},{"name":"Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary","place":["Calgary, Canada"]},{"name":"Department of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine, University of Calgary","place":["Calgary, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Romagnani","sequence":"additional","affiliation":[{"name":"Institute for Medical Immunology, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin","place":["Berlin, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Colom\u00e9-Tatch\u00e9","sequence":"additional","affiliation":[{"name":"Biomedical Center, Physiological Chemistry, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-0151","authenticated-orcid":false,"given":"Barbara U.","family":"Schraml","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Biomedical Center Munich, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]},{"name":"Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t in Munich","place":["Planegg-Martinsried, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3712"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-061020-053707"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149513"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0210-z"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines4020008"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.042"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.001"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01545-7"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.add4132"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20659-2"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.07.001"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.035"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062648"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2679"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46966-6"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.017"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31054-4"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.008"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.003"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4812"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110051"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12240"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05141-x"},{"key":"e_1_3_4_24_2","first-page":"1","article-title":"Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2","volume":"12","author":"Zhou L.","year":"2019","unstructured":"L. Zhou , Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nat. Publish. Group 12, 1\u201323 (2019).","journal-title":"Nat. Publish. Group"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04934-4"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.014"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04136-4"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01247-6"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05089-y"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05309-5"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00906-5"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00074.x"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.86"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181430"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl5053"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.08.005"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2318710120"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.04.002"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109686"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47647-0"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.07.014"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1096472"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747388"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.11.3489"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501380"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3365"},{"key":"e_1_3_4_47_2","first-page":"jem.20150642-19","article-title":"Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses","volume":"63","author":"Lau C. M.","year":"2016","unstructured":"C. M. Lau , Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses. J. Exp. Med. 63, jem.20150642-19 (2016).","journal-title":"J. Exp. Med."},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01024-x"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.11.004"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1444"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01206-w"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl4896"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03852-1"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00789-y"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14118-w"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmeth.2023.100533"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-176321"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.008"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-023-01938-4"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.252734.114"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07182"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406908111"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1136080"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201948497"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119605"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.06.015"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071364"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0713169"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107698"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.12.012"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.05.013"},{"key":"e_1_3_4_72_2","doi-asserted-by":"crossref","unstructured":"L. Fu ROR\u03b3t-dependent antigen-presenting cells direct regulatory T cell-mediated tolerance to food antigen. bioRxiv [Preprint] (2024) 10.1101\/2024.07.23.604803 (Accessed 20 August 2024).","DOI":"10.1101\/2024.07.23.604803"},{"key":"e_1_3_4_73_2","doi-asserted-by":"crossref","unstructured":"A. Rudnitsky H. Oh J. Talmor R. Kedmi Coordinated network of T cells and antigen presenting cells regulate tolerance to food. bioRxiv [Preprint] (2024) 10.1101\/2024.07.11.603064 (Accessed 20 August 2024).","DOI":"10.1101\/2024.07.11.603064"},{"key":"e_1_3_4_74_2","doi-asserted-by":"crossref","unstructured":"Y. F. Parisotto Thetis cells induce food-specific Treg cell differentiation and oral tolerance. bioRxiv [Preprint] (2024) 10.1101\/2024.05.08.592952 (Accessed 20 August 2024).","DOI":"10.1101\/2024.05.08.592952"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.02.002"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104827"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.10.031"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1332386"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.12.005"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2017626117"},{"key":"e_1_3_4_81_2","unstructured":"H. Narasimhan M. Richter B. Schraml Data from \u201cROR\u03b3t-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen presenting cells\u201d. Biostudies. http:\/\/www.ebi.ac.uk\/biostudies\/studies\/S-BSST1322. Deposited 31 January 2025."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2417308122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T15:09:48Z","timestamp":1740409788000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2417308122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,3,4]]}},"alternative-id":["10.1073\/pnas.2417308122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2417308122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"2024-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2417308122"}}