{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:54:09Z","timestamp":1781106849828,"version":"3.54.1"},"reference-count":51,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019899","name":"Alliance Nationale pour les Sciences de la Vie et de la Sant\u00e9","doi-asserted-by":"publisher","award":["ITMO Cancer of Aviesan"],"award-info":[{"award-number":["ITMO Cancer of Aviesan"]}],"id":[{"id":"10.13039\/100019899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["PRCE2025 PRoBUS"],"award-info":[{"award-number":["PRCE2025 PRoBUS"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,5,6]]},"abstract":"<jats:p>\n                    Dynamic elastography uses an imaging system to visualize the propagation of elastic waves, the speed of which is directly related to the elasticity felt by palpation. Very few studies have focused on X-ray elastography because of the technical challenges it poses: a planar image of an integration volume at a very slow sampling rate. We demonstrate that tracking a slow elastic wave guided along a one-dimensional structure could provide a possible solution. The recently discovered flexural pulse wave, which is naturally generated by heartbeats and propagates along arteries, is the perfect candidate for X-ray elastography. As it reflects the cardiovascular health of patients, arterial elasticity is a biomarker of high clinical interest. We first validate the method by measuring the elasticity in artery phantoms using X-ray. We then move on to data obtained in vivo on coronary arteries during a routine angiography examination. During coronary angiography, a catheter is used to inject an X-ray contrast dye into the patient\u2019s aorta. X-rays are then taken as the dye spreads through the coronary arteries. It shows the movement of the coronary arteries for a few seconds and provides an opportunity to follow the natural flexural pulse waves. The obtained Young\u2019s moduli for two patients are\n                    <jats:italic toggle=\"yes\">E<\/jats:italic>\n                    = 38 \u00b1 30 kPa and\n                    <jats:italic toggle=\"yes\">E<\/jats:italic>\n                    = 36 \u00b1 28 kPa, respectively. These preliminary results are expected to pave the way for X-ray elastography.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2419060122","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:02:52Z","timestamp":1745928172000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Toward quantitative X-ray elastography of coronary arteries using flexural pulse waves"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5163-3557","authenticated-orcid":false,"given":"Sibylle","family":"Gregoire","sequence":"first","affiliation":[{"name":"Laboratory of Therapeutic Applications of Ultrasound, French National Institute of Health and Medical Research, Universit\u00e9 Lyon 1","place":["Lyon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-5203","authenticated-orcid":false,"given":"Gabrielle","family":"Laloy-Borgna","sequence":"additional","affiliation":[{"name":"Department of Imaging Physics","place":["Delft, The Netherlands"]},{"name":"Delft University of Technology","place":["Delft, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rouviere","sequence":"additional","affiliation":[{"name":"Department of Radiology","place":["Lyon, France"]},{"name":"H\u00f4pital Edouard Herriot, Hospices Civils de Lyon","place":["Lyon, France"]},{"name":"Universit\u00e9 Lyon 1","place":["Lyon, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-1915","authenticated-orcid":false,"given":"Bruno","family":"Giammarinaro","sequence":"additional","affiliation":[{"name":"Laboratory of Therapeutic Applications of Ultrasound, French National Institute of Health and Medical Research, Universit\u00e9 Lyon 1","place":["Lyon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-4120","authenticated-orcid":false,"given":"Stefan","family":"Catheline","sequence":"additional","affiliation":[{"name":"Laboratory of Therapeutic Applications of Ultrasound, French National Institute of Health and Medical Research, Universit\u00e9 Lyon 1","place":["Lyon"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"1","article-title":"A pulsed doppler ultrasonic system for making noninvasive measurements of the mechanical properties of soft tissue","volume":"24","author":"Krouskop T.","year":"1987","unstructured":"T. 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