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In multiple mouse tumor models, M-Ad5 induced a robust antitumor immune response by reprogramming the immunosuppressive tumor microenvironment, and potentiated the response to immune checkpoint inhibitors by recruiting more immune cells. We demonstrated that M-Ad5 in combination with PDL1 inhibitors activated tumor antigen-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and memory T cells, thereby suppressing the growth of CT26 colorectal cancer metastasis, and preventing postsurgical B16F10 cancer recurrence and metastatic spread, as well as providing long-term immune protection against the rechallenged tumors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2419694123","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:47:32Z","timestamp":1770832052000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["Intravenous infusion of engineered megakaryocytes to produce oncolytic platelets in vivo for enhanced cancer 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