{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:19:07Z","timestamp":1793380747871,"version":"4.5.0"},"reference-count":61,"publisher":"National Academy of Sciences","issue":"7","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["GM138210"],"award-info":[{"award-number":["GM138210"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,2,18]]},"abstract":"<jats:p>\n                    Microbes use quorum-sensing systems to respond to ecological and environmental changes. In the oral microbiome, the pathogenic bacterium\n                    <jats:italic>Streptococcus mutans<\/jats:italic>\n                    uses quorum-sensing to control the production of bacteriocins. These antimicrobial peptides kill off ecological competitors and allow\n                    <jats:italic>S. mutans<\/jats:italic>\n                    to dominate the microenvironment of dental plaques and form dental caries. One class of bacteriocins produced by\n                    <jats:italic>S. mutans<\/jats:italic>\n                    , the lantibiotic mutacins, are particularly effective at killing due to their broad spectrum of activity. Despite years of study, the regulatory mechanisms governing production of lantibiotic mutacins I, II, and III in\n                    <jats:italic>S. mutans<\/jats:italic>\n                    have never been elucidated. We identified a distinct class of quorum-sensing system, MutRS, that regulates mutacins and is widespread among the streptococci. We demonstrate that MutRS systems are activated by a short peptide pheromone (Mutacin Stimulating Peptide) and show that MutRS controls production of three separate lantibiotic mutacins in three different strains of\n                    <jats:italic>S. mutans<\/jats:italic>\n                    . Finally, we show that paralogous MutRS systems participate in inter- and intrastrain crosstalk, providing further evidence of the interplay between quorum-sensing systems in the oral streptococci.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2421164122","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T14:19:06Z","timestamp":1739456346000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":11,"title":["The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogen\n                    <i>Streptococcus mutans<\/i>"],"prefix":"10.1073","volume":"122","author":[{"given":"Ryan M.","family":"Wyllie","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering","place":["Ann Arbor"]},{"name":"University of Michigan","place":["Ann Arbor"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-9836","authenticated-orcid":false,"given":"Paul A.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Ann Arbor"]},{"name":"University of Michigan","place":["Ann Arbor"]},{"name":"Department of Chemical Engineering","place":["Ann Arbor"]},{"name":"University of Michigan","place":["Ann Arbor"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"7","volume-title":"Global oral health status report: towards universal health coverage for oral health by 2030","author":"World Health Organization","year":"2022","unstructured":"World Health Organization, \u201cThe burden of the main oral diseases\u201d in Global oral health status report: towards universal health coverage for oral health by 2030. 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