{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:49:42Z","timestamp":1788493782963,"version":"build-2803163510"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"14","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R35 NS 097343-08"],"award-info":[{"award-number":["R35 NS 097343-08"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001201","name":"Kavli Foundation","doi-asserted-by":"publisher","award":["LS-2024 GR-41-3017"],"award-info":[{"award-number":["LS-2024 GR-41-3017"]}],"id":[{"id":"10.13039\/100001201","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000153","name":"NSF | BIO | Division of Biological Infrastructure","doi-asserted-by":"publisher","award":["NiCE: IOS-2426394"],"award-info":[{"award-number":["NiCE: IOS-2426394"]}],"id":[{"id":"10.13039\/100000153","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,4,8]]},"abstract":"<jats:p>\n                    The nematode\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    feeds by rhythmic contraction and relaxation of a neuromuscular organ called the pharynx, which draws in and filters water and bacterial food. This behavior is driven by myogenic plateau potentials, long-lasting depolarizations of the pharyngeal muscle, which are timed by neuronal input from a dedicated pharyngeal nervous system. While the timing of these plateaus\u2019 initiation has received significant attention, their mechanisms of termination remain incompletely understood. In particular, it is unclear how plateaus resist early termination by hyperpolarizing current noise. Here, we present a computational model of pharyngeal plateaus against a noisy background. We propose that an unusual, rapidly inactivating potassium conductance confers exceptional noise robustness on the system. We further investigate the possibility that a similar mechanism in other systems permits switching between plateau and spiking behavior under noisy conditions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2422709122","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T23:43:22Z","timestamp":1743723802000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["An unusual potassium conductance protects\n                    <i>Caenorhabditis elegans<\/i>\n                    pharyngeal muscle rhythms against environmental noise"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3452-6508","authenticated-orcid":false,"given":"Max","family":"Kenngott","sequence":"first","affiliation":[{"name":"Volen Center for Complex Systems","place":["Waltham"]},{"name":"Brandeis University","place":["Waltham"]},{"name":"Department of Physics","place":["Waltham"]},{"name":"Brandeis University","place":["Waltham"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7468-0035","authenticated-orcid":false,"given":"Piali","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Biology","place":["Waltham"]},{"name":"Brandeis University","place":["Waltham"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-7989","authenticated-orcid":false,"given":"Shawn","family":"Lockery","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience","place":["Eugene"]},{"name":"University of Oregon","place":["Eugene"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9632-5448","authenticated-orcid":false,"given":"Eve","family":"Marder","sequence":"additional","affiliation":[{"name":"Volen Center for Complex Systems","place":["Waltham"]},{"name":"Brandeis University","place":["Waltham"]},{"name":"Department of Biology","place":["Waltham"]},{"name":"Brandeis University","place":["Waltham"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.00433"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90207-0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/worm.21833"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24932"},{"key":"e_1_3_4_5_2","first-page":"299","article-title":"The pharynx of Caenorhabditis elegans","volume":"275","author":"Albertson D. 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