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We simultaneously recorded from adjacent spiny projection neurons (&lt;5\u201310 \u03bcm) in whole-cell patch mode and demonstrated a fast synaptic connection between 26\/69 pairs in cortex-striatum-substantia nigra organotypic cultures and 5\/38 pairs in acute striatal slices. The synapse, which was blocked by \u03b3-aminobutyric acid type A antagonists, displayed a wide range of failure rates, was depolarizing at rest, and reversed above \u221260 mV. Presynaptic bursts of action potentials were highly correlated with total postsynaptic depolarization at rest. Synaptic transmission was optimized for burst discharge &gt;14 Hz and showed considerable short-term plasticity, including paired-pulse depression at intervals &lt;25 ms, intraburst facilitation, and interburst augmentation. This activity-dependent collateral interaction provides the basis for a new class of basal ganglia models in which striatal neurons cooperate as well as compete during processing of cortical inputs.<\/jats:p>","DOI":"10.1073\/pnas.242428599","type":"journal-article","created":{"date-parts":[[2002,11,26]],"date-time":"2002-11-26T12:42:52Z","timestamp":1038314572000},"page":"15764-15769","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":163,"title":["Fast synaptic transmission between striatal spiny projection neurons"],"prefix":"10.1073","volume":"99","author":[{"given":"Uwe","family":"Czubayko","sequence":"first","affiliation":[{"name":"Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892; and Department of Anatomy and Neurobiology, University of Tennessee College of Medicine, 875 Monroe Avenue, Memphis, TN 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietmar","family":"Plenz","sequence":"additional","affiliation":[{"name":"Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892; and Department of Anatomy and Neurobiology, University of Tennessee College of Medicine, 875 Monroe Avenue, Memphis, TN 38163"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,11,18]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)62678-3"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90106-K"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-07-02397.1996"},{"key":"#cr-split#-e_1_3_3_4_2.1","unstructured":"Ramon y Cajal S. 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