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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Tissue fibrosis is commonly associated with organ malfunction and is strongly associated with the development of chronic rejection, cardiovascular diseases, and other chronic diseases. Fibrosis also contributes to immune exclusion in tumor tissues. Targeting fibrosis might be a strategy for prolonging allograft survival while suppressing cancer development. Here, single-cell transcriptomes of human and mouse heart allografts showed that macrophages accumulated in grafts with fibrosis were reprogrammed via histone methylation regulated by Setdb1, an H3K9 methyltransferase. Myeloid-specific deletion of Setdb1 prolonged heart allograft survival but reversed immune exclusion in tumor tissues. Interestingly, myeloid-specific Setdb1-knockout led to lower fibrosis in heart allografts and tumor tissues in mice. Our single-cell sequencing data showed that Setdb1 ablation impaired Fn1\n                    <jats:sup>+<\/jats:sup>\n                    and SPP1\n                    <jats:sup>+<\/jats:sup>\n                    profibrogenic macrophage reprogramming. Mechanistically, Fn1, which was induced by the CCR2-Creb\/Setdb1 axis, upregulated the expression of genes related to fibrosis in fibroblasts and macrophages via ITGA5 and PIRA receptors. Blocking the interaction between FN1 and these receptors inhibited fibrosis in allograft and tumor tissues. Our results reveal a target, histone methylation in macrophages, for the treatment of fibrosis-related disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2424534122","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T11:37:29Z","timestamp":1750765049000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["Setdb1 ablation in macrophages attenuates fibrosis in heart allografts"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0747-5916","authenticated-orcid":false,"given":"Zhibo","family":"Ma","sequence":"first","affiliation":[{"name":"Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology","place":["Wuhan, People\u2019s Republic of China"]},{"name":"Key Laboratory of Organ Transplantation, Ministry of Education","place":["Wuhan, People\u2019s Republic of 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Ma Transcriptome RNA-seq analysis for WT and Setdb1 cko mice BMDMs. Genome Sequence Archive. https:\/\/ngdc.cncb.ac.cn\/gsa\/search?searchTerm=CRA012968. Deposited 8 October 2023."},{"key":"e_1_3_5_52_2","unstructured":"Z. Ma A H3K4me3 Chip-seq analysis from wt and setdb1 Cko BMDMs. Genome Sequence Archive. https:\/\/ngdc.cncb.ac.cn\/gsa\/search?searchTerm=CRA015075. Deposited 26 February 2024."},{"key":"e_1_3_5_53_2","unstructured":"Z. Ma Single-nuclear gene expression profiles of cells of WT and Setdb1 cko mice allografts. Genome Sequence Archive. https:\/\/ngdc.cncb.ac.cn\/gsa\/search?searchTerm=CRA013001. Deposited 11 October 2023."},{"key":"e_1_3_5_54_2","unstructured":"K. Amancherla Single-nuclear gene expression profiles of cells of human myocardial tissue obtained after heart transplantation. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE203548. Deposited 7 June 2022."},{"key":"e_1_3_5_55_2","unstructured":"H. Suryawanshi T. Muthukumar P. Morozov Single cell transcriptomics of human native kidney and kidney allografts. Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE151671. 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