{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:05:19Z","timestamp":1782399919835,"version":"3.54.5"},"reference-count":66,"publisher":"National Academy of Sciences","issue":"17","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H01400"],"award-info":[{"award-number":["17H01400"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H04806"],"award-info":[{"award-number":["21H04806"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K08009"],"award-info":[{"award-number":["23K08009"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K06400"],"award-info":[{"award-number":["23K06400"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23ama221117h0002"],"award-info":[{"award-number":["23ama221117h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["24gm1710007s0102"],"award-info":[{"award-number":["24gm1710007s0102"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research on Innovative Areas","award":["25126719"],"award-info":[{"award-number":["25126719"]}]},{"DOI":"10.13039\/501100007951","name":"Tokyo Medical and Dental University","doi-asserted-by":"publisher","award":["Nanken-Kyoten"],"award-info":[{"award-number":["Nanken-Kyoten"]}],"id":[{"id":"10.13039\/501100007951","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K01941"],"award-info":[{"award-number":["24K01941"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23H04946"],"award-info":[{"award-number":["23H04946"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21zf0127001"],"award-info":[{"award-number":["JP21zf0127001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"MEXT | JST | Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","award":["JPMJCR2123"],"award-info":[{"award-number":["JPMJCR2123"]}],"id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM144426"],"award-info":[{"award-number":["R01GM144426"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["World Premier International Research Center Initiative"],"award-info":[{"award-number":["World Premier International Research Center Initiative"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["Human Biology-Microbiome-Quantum Research Center"],"award-info":[{"award-number":["Human Biology-Microbiome-Quantum Research Center"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:p>\n                    There is currently a global epidemic of obesity and obesity-related diseases such as type 2 diabetes due to decreased physical activity, excessive food intake, and\/or genetic predisposition. The Hippo-YAP1 pathway has attracted attention as a potential therapeutic target because YAP1\/TAZ activation in murine immature adipocytes in vitro suppresses their differentiation by inhibiting PPAR\u03b3 activity. However, the role of YAP1 activation in mature adipocytes in vivo remains unclear. MOB1, whose expression is increased in obesity, is the hub of the Hippo core molecule complex and negatively regulates YAP1\/TAZ activation. Therefore, we generated aMob1DKO mutant mice, which feature deficiency of\n                    <jats:italic>Mob1a\/b<\/jats:italic>\n                    specifically in mature adipocytes. Compared to controls, aMob1DKO mice subjected to a high-fat diet showed beneficial changes consistent with resistance to diet-induced obesity. The mutants exhibited increases in basal lipolysis, \u201cbeiging,\u201d and energy expenditure, as well as suppression of ROS production and inflammation in white adipose tissue. Insulin sensitivity and glucose tolerance were improved, and ectopic fat accumulation was reduced. Most of these changes were dependent on the YAP1 activation observed in mature white adipose tissue of aMob1DKO mice. FGF21, which improves lipid metabolism, was upregulated directly via YAP1 activation, and many of the phenotypes seen in aMob1DKO mice were also dependent on FGF21. Thus, the aMob1DKO mouse is an interesting model for the study of the metabolic effects of diet-induced obesity and protection against diabetes. Our work suggests that a YAP1-FGF21 axis exists in adipocytes that may be a potential therapeutic target for obesity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2424741122","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T15:07:51Z","timestamp":1745248071000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes"],"prefix":"10.1073","volume":"122","author":[{"given":"Miki","family":"Nishio","sequence":"first","affiliation":[{"name":"Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Otani","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Yuguchi","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1073-2745","authenticated-orcid":false,"given":"Daisuke","family":"Kohno","sequence":"additional","affiliation":[{"name":"Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University","place":["Maebashi, Gunma, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-1915","authenticated-orcid":false,"given":"Tsutomu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University","place":["Maebashi, Gunma, Japan"]},{"name":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-8740","authenticated-orcid":false,"given":"Tadahiro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University","place":["Maebashi, Gunma, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-2509","authenticated-orcid":false,"given":"Tomoyoshi","family":"Soga","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University","place":["Tsuruoka, Yamagata, Japan"]},{"name":"Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), Keio University","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Faculty of Science and Engineering, Waseda University","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2963-4501","authenticated-orcid":false,"given":"Atsuo T.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University","place":["Tsuruoka, Yamagata, Japan"]},{"name":"Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine","place":["Cincinnati"]},{"name":"Department of Clinical and Molecular Genetics, Hiroshima University Hospital","place":["Hiroshima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Oshima","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine","place":["Cincinnati"]},{"name":"Department of Urology, Jichi Medical University","place":["Saitama, Japan"]},{"name":"Saitama Medical Center","place":["Saitama, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hikasa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, University of Occupational and Environmental Health","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Woo","sequence":"additional","affiliation":[{"name":"Banting and Best Diabetes Centre, University of Toronto","place":["Toronto, Canada"]},{"name":"Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto and University Health Network","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nishina","sequence":"additional","affiliation":[{"name":"Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuwa","family":"Nakao","sequence":"additional","affiliation":[{"name":"Medical Innovation Center, Graduate School of Medicine, Kyoto University","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Maehama","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]},{"name":"Department of Biochemistry, Showa Medical University School of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-8808","authenticated-orcid":false,"given":"Akira","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine","place":["Kobe, Hyogo, Japan"]},{"name":"Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo","place":["Tokyo, Japan"]},{"name":"Department of Biochemistry, Showa Medical University School of Medicine","place":["Tokyo, Japan"]},{"name":"Japan Baptist Hospital","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-062053"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.059"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2391"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.761488"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-002-0873-y"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.204"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00541-x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00185"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20190468"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051619898"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.09.003"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.12.2882"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77812"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.06.008"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114465"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.170431"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00360.2006"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M808742200"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12106936"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17399"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081386"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.05.031"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1032"},{"key":"e_1_3_4_25_2","first-page":"237","article-title":"Targeting the Hippo signalling pathway for cancer treatment","volume":"161","author":"Nakatani K.","year":"2017","unstructured":"K. Nakatani , Targeting the Hippo signalling pathway for cancer treatment. J. Biochem. 161, 237\u2013244 (2017).","journal-title":"J. Biochem."},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2011.04.007"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110955"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003608"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29265"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.10.037"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00201.2007"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.10.003"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01664.x"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2015.0100"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19229-3"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63735"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306871"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.12.018"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00107"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.09.018"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2358-6"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2011.365"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.2337\/db22-0450"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00497-2"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28383"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.003"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006962107"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00037"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.03.005"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.05.026"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2018.05.012"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.07.012"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M058610"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904187106"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31785-9"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00680-9"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.01.006"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1778-4159"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2008-0007"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.07.003"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1159\/000495896"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000626"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac189"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800280-3.00010-4"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200250-JLR200"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.51.36281"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2424741122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T15:08:15Z","timestamp":1745248095000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2424741122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":66,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,4,29]]}},"alternative-id":["10.1073\/pnas.2424741122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2424741122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"assertion":[{"value":"2024-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2424741122"}}