{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:25:40Z","timestamp":1793075140134,"version":"4.5.0"},"reference-count":67,"publisher":"National Academy of Sciences","issue":"30","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["U54CA268084"],"award-info":[{"award-number":["U54CA268084"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["U54CA193419"],"award-info":[{"award-number":["U54CA193419"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA228272"],"award-info":[{"award-number":["R01CA228272"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA225002"],"award-info":[{"award-number":["R01CA225002"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA155284"],"award-info":[{"award-number":["R01CA155284"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"HHS | NIH | National Cancer Institute","doi-asserted-by":"publisher","award":["R01CA165309"],"award-info":[{"award-number":["R01CA165309"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32AI083216"],"award-info":[{"award-number":["T32AI083216"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000150","name":"NSF | ENG | Division of Emerging Frontiers and Multidisciplinary Activities","doi-asserted-by":"publisher","award":["EFMA-1830961"],"award-info":[{"award-number":["EFMA-1830961"]}],"id":[{"id":"10.13039\/100000150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000150","name":"NSF | ENG | Division of Emerging Frontiers and Multidisciplinary Activities","doi-asserted-by":"publisher","award":["EFMA-1830968"],"award-info":[{"award-number":["EFMA-1830968"]}],"id":[{"id":"10.13039\/100000150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000146","name":"NSF | ENG | Division of Chemical, Bioengineering, Environmental, and Transport Systems","doi-asserted-by":"publisher","award":["CBET-1249311"],"award-info":[{"award-number":["CBET-1249311"]}],"id":[{"id":"10.13039\/100000146","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000150","name":"NSF | ENG | Division of Emerging Frontiers and Multidisciplinary Activities","doi-asserted-by":"publisher","award":["EFRI-1240416"],"award-info":[{"award-number":["EFRI-1240416"]}],"id":[{"id":"10.13039\/100000150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000082","name":"NSF | EDU | Division of Graduate Education","doi-asserted-by":"publisher","award":["DGE-1842165"],"award-info":[{"award-number":["DGE-1842165"]}],"id":[{"id":"10.13039\/100000082","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011252","name":"Lefkofsky Family Foundation","doi-asserted-by":"publisher","award":["Innovation Award"],"award-info":[{"award-number":["Innovation Award"]}],"id":[{"id":"10.13039\/100011252","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017011","name":"Chicago Biomedical Consortium","doi-asserted-by":"publisher","award":["Funded Lever Award"],"award-info":[{"award-number":["Funded Lever Award"]}],"id":[{"id":"10.13039\/100017011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001032","name":"Chicago Community Trust","doi-asserted-by":"publisher","award":["Searle Funds"],"award-info":[{"award-number":["Searle Funds"]}],"id":[{"id":"10.13039\/100001032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,7,29]]},"abstract":"<jats:p>Cancer cells exhibit a remarkable resilience to cytotoxic stress, often adapting through transcriptional changes linked to alterations in chromatin structure. In several types of cancer, these adaptations involve epigenetic modifications and restructuring of topologically associating domains. However, the underlying principles by which chromatin architecture facilitates such adaptability across different cancers remain poorly understood. To investigate the role of chromatin in this process, we developed a physics-based model that connects chromatin organization to cell fate decisions, such as survival following chemotherapy. Our model builds on the observation that chromatin forms packing domains, which influence transcriptional activity through macromolecular crowding. The model accurately predicts chemoevasion in vitro, suggesting that changes in packing domains affect the likelihood of survival. Consistent results across diverse cancer types indicate that the model captures fundamental principles of chromatin-mediated adaptation, independent of the specific cancer or chemotherapy mechanisms involved. Based on these insights, we hypothesized that compounds capable of modulating packing domains, termed Transcriptional Plasticity Regulators (TPRs), could prevent cellular adaptation to chemotherapy. We conducted a proof-of-concept compound screen using live-cell chromatin imaging to identify several TPRs that synergistically enhanced chemotherapy-induced cell death. The most effective TPR significantly improved therapeutic outcomes in a patient-derived xenograft model of ovarian cancer. These findings underscore the central role of chromatin in cellular adaptation to cytotoxic stress and present a framework for enhancing cancer therapies, with broad potential across multiple cancer types.<\/jats:p>","DOI":"10.1073\/pnas.2425319122","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T15:16:49Z","timestamp":1753197409000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":6,"title":["Leveraging chromatin packing domains to target chemoevasion in vivo"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3007-9197","authenticated-orcid":false,"given":"Jane","family":"Frederick","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranya K. A.","family":"Virk","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Department of Pharmaceutical Chemistry","place":["San Francisco"]},{"name":"University of California","place":["San Francisco"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-8900","authenticated-orcid":false,"given":"I Chae","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luay M.","family":"Almassalha","sequence":"additional","affiliation":[{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Department of Gastroenterology and Hepatology","place":["Chicago"]},{"name":"Feinberg School of Medicine","place":["Chicago"]},{"name":"Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta M.","family":"Wodarcyk","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"VanDerway","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1008-2844","authenticated-orcid":false,"given":"Ruyi","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0909-9647","authenticated-orcid":false,"given":"Cody L.","family":"Dunton","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3599-4443","authenticated-orcid":false,"given":"Tiffany","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla I.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Loxas","sequence":"additional","affiliation":[{"name":"Department of Pathology","place":["Chicago"]},{"name":"Feinberg School of Medicine","place":["Chicago"]},{"name":"Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9309-6544","authenticated-orcid":false,"given":"Jared T.","family":"Ahrendsen","sequence":"additional","affiliation":[{"name":"Department of Pathology","place":["Chicago"]},{"name":"Feinberg School of Medicine","place":["Chicago"]},{"name":"Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-3999","authenticated-orcid":false,"given":"Demirkan B.","family":"Gursel","sequence":"additional","affiliation":[{"name":"Department of Pathology","place":["Chicago"]},{"name":"Feinberg School of Medicine","place":["Chicago"]},{"name":"Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-0913","authenticated-orcid":false,"given":"Paola Carrillo","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-0249","authenticated-orcid":false,"given":"Rikkert J.","family":"Nap","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2214-2842","authenticated-orcid":false,"given":"Saira","family":"John","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0913-9298","authenticated-orcid":false,"given":"Vasundhara","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2882-2471","authenticated-orcid":false,"given":"Nicholas M.","family":"Anthony","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3245-099X","authenticated-orcid":false,"given":"John","family":"Carinato","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-3674","authenticated-orcid":false,"given":"Wing Shun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3005-0164","authenticated-orcid":false,"given":"Rivaan","family":"Kakkaramadam","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surbhi","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohreh","family":"Shahabi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology","place":["Chicago"]},{"name":"Feinberg School of Medicine","place":["Chicago"]},{"name":"Prentice Women\u2019s Hospital","place":["Chicago"]},{"name":"Northwestern University","place":["Chicago"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-048X","authenticated-orcid":false,"given":"Guillermo A.","family":"Ameer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-0335","authenticated-orcid":false,"given":"Igal G.","family":"Szleifer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Department of Chemistry","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-1818","authenticated-orcid":false,"given":"Vadim","family":"Backman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Center for Physical Genomics and Engineering","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]},{"name":"Chemistry of Life Processes Institute","place":["Evanston"]},{"name":"Department of Biomedical Engineering","place":["Evanston"]},{"name":"Northwestern University","place":["Evanston"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26687"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06054-z"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1907-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1364"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0648-6"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-00302-4"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature16490"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad9024"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.030"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-2026-y"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-016-0245-y"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl081"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.116"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1638"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.02.019"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005122"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.11.007"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax6232"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe4310"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adq6652"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-16028-2"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608198113"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-025-01786-1"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0153-2"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba8811"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2012.155"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.025"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26328-2"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1272403"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.111.033903"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1364\/OL.39.004290"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1364\/OL.400231"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep15623"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-005-0148-7"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602215"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3892\/or_00000963"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62146-7"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2020.102988"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.02.024"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.03.010"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.023"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.10.2081"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1274"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2015.04.039"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.90073"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1063\/5.0241529"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-05-0286"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.02.032"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.09-21"},{"key":"e_1_3_4_50_2","first-page":"12","article-title":"Chromatin organization governs transcriptional response and plasticity of Cancer stem cells","volume":"2407426","author":"Wang Y.","year":"2025","unstructured":"Y. Wang , Chromatin organization governs transcriptional response and plasticity of Cancer stem cells. Adv. Sci. 2407426, 12 (2025).","journal-title":"Adv. Sci."},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.05.017"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00071"},{"key":"e_1_3_4_53_2","first-page":"4557","article-title":"Stromal tumor-infiltrating lymphocytes evaluated on H&E-stained slides are an independent prognostic factor in epithelial ovarian Cancer and ovarian serous carcinoma","volume":"17","author":"Hwang C.","year":"2019","unstructured":"C. Hwang , Stromal tumor-infiltrating lymphocytes evaluated on H&E-stained slides are an independent prognostic factor in epithelial ovarian Cancer and ovarian serous carcinoma. Oncol. Lett. 17, 4557\u20134565 (2019).","journal-title":"Oncol. Lett."},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-10-0317"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.06.015"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26407-4"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-021-00349-4"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08880-4"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05668-3"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature22794"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05311-x"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E19-09-0515"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03796-6"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12518"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.645593"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8659"},{"key":"e_1_3_4_67_2","unstructured":"J. Frederick BackmanLab\/CDA Paper. Github. https:\/\/github.com\/BackmanLab\/CDA_Paper. Deposited 4 December 2024."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2425319122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T15:17:02Z","timestamp":1753197422000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2425319122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":67,"journal-issue":{"issue":"30","published-print":{"date-parts":[[2025,7,29]]}},"alternative-id":["10.1073\/pnas.2425319122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2425319122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2024-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2425319122"}}