{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:28:33Z","timestamp":1791293313502,"version":"4.1.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,11,26]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>Mecp2<\/jats:italic>\n                    gene has been shown to be mutated in most cases of human Rett syndrome, and mouse models deleted for the ortholog have been generated. Lineage-specific deletion of the gene indicated that the Rett-like phenotype is caused by\n                    <jats:italic>Mecp2<\/jats:italic>\n                    deficiency in neurons. Biochemical evidence suggests that\n                    <jats:italic>Mecp2<\/jats:italic>\n                    acts as a global transcriptional repressor, predicting that mutant mice should have genome-wide transcriptional deregulation. We tested this hypothesis by comparing global gene expression in wild-type and\n                    <jats:italic>Mecp2<\/jats:italic>\n                    mutant mice. The results of numerous microarray analyses revealed no dramatic changes in transcription even in mice displaying overt disease symptoms, although statistical power analyses of the data indicated that even a small number of relatively subtle changes in transcription would have been detected if present. However, a classifier consisting of a combined small set of genes was able to distinguish between mutant and wild-type samples with high accuracy. This result suggests that\n                    <jats:italic>Mecp2<\/jats:italic>\n                    deficiency leads to subtle gene expression changes in mutant brains which may be associated with the phenotypic changes observed.\n                  <\/jats:p>","DOI":"10.1073\/pnas.242566899","type":"journal-article","created":{"date-parts":[[2002,11,26]],"date-time":"2002-11-26T12:42:52Z","timestamp":1038314572000},"page":"15536-15541","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":304,"title":["Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain"],"prefix":"10.1073","volume":"99","author":[{"given":"Matthew","family":"Tudor","sequence":"first","affiliation":[{"name":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142; Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01613; and Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schahram","family":"Akbarian","sequence":"additional","affiliation":[{"name":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142; Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01613; and Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Z.","family":"Chen","sequence":"additional","affiliation":[{"name":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142; Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01613; and Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Jaenisch","sequence":"additional","affiliation":[{"name":"Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142; Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01613; and Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA 19486"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,11,13]]},"reference":[{"key":"e_1_3_3_1_2","unstructured":"McKusick-Nathans Institute for Genetic Medicine (2000) Online Mendelian Inheritance in Man (National Center for Biotechnology Information National Library of Medicine) www.ncbi.nlm.nih.gov\/omin\/."},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140412"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.8.1188"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/088307389801300507"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/301932"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.8.1581"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/13810"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.16.2365"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(00)00083-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/302690"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90610-O"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/561"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/30764"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/85906"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/85899"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.23.3136"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80853-3"},{"key":"e_1_3_3_18_2","unstructured":"Kikinis Z. & Lee P. (2000)."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.6.2907"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.1.31"},{"key":"e_1_3_3_21_2","unstructured":"Dudoit S. Yang Y. H. Callo M. & Speed T. (2000) Technical Report #578 (Univ. of California Press Berkeley)."},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1089\/10665270050514945"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5439.531"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1013699998"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.8.685"},{"key":"e_1_3_3_26_2","unstructured":"Tamayo P. Ohm K. Subarmanian A. Ross K. Angelo M. & Golub T. (2002) GENECLUSTER VERSION 2 (Whitehead Institute\/MIT Center for Genome Research Cambridge MA)."},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979737"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.399"},{"key":"e_1_3_3_29_2","first-page":"75","volume":"6","author":"Kaufmann W. E.","year":"1997","unstructured":"Kaufmann W. E., Taylor, C. V., Hohmann, C. F., Sanwal, I. B. & Naidu, S. (1997) Eur. Child Adolesc. Psychiatry6,75-77.9452926","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199811000-00003"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6023"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0428"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/415436a"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0102-68"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5287.540"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.14863"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/12659"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.4.1394-1406.2000"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.11.6538"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.194101"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.2.226"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.3.405"},{"key":"e_1_3_3_43_2","unstructured":"Traynor J. Agarwal P. Lazzeroni L. & Francke U. (2002) BMC Med. Genet. in press."},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00768-7"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.242566899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T20:55:41Z","timestamp":1650920141000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.242566899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,13]]},"references-count":44,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2002,11,26]]}},"alternative-id":["10.1073\/pnas.242566899"],"URL":"https:\/\/doi.org\/10.1073\/pnas.242566899","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,13]]},"assertion":[{"value":"2002-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2002-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}