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It represents evidence hitherto unavailable, both for this species and the human fossil record in general, and sheds light on the possible influence of respiratory adaptations on the characteristic Neanderthal facial morphology. Part of the debate has revolved around inner nasal traits proposed as unique adaptations (autapomorphies) of the species\n                    <jats:italic toggle=\"yes\">Homo neanderthalensis<\/jats:italic>\n                    in relation to cold climate, specifically: a vertically oriented medial projection and a medial swelling on the nasal cavity wall alongside the lack of an ossified roof over the lacrimal groove. The lack of complete anatomy in the Neanderthal fossil record further livened the discussion regarding their occurrence. With the description and analysis of this unique finding, we can rule out the existence of such features. In addition, our observations corroborate the hypothesis that the characteristic midfacial morphology of\n                    <jats:italic toggle=\"yes\">H. neanderthalensis<\/jats:italic>\n                    (i.e., the midfacial prognathism) is the result of a combination of factors and not a direct result of respiratory adaptations in the upper airways. Finally, our data provide an enhanced perspective for modeling Neanderthal respiratory performances.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2426309122","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T20:00:52Z","timestamp":1763409652000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["The first preserved nasal cavity in the human fossil record: The Neanderthal from Altamura"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-2990","authenticated-orcid":false,"given":"Costantino","family":"Buzi","sequence":"first","affiliation":[{"name":"Institut Catal\u00e0 de Paleoecologia Humana i Evoluci\u00f3 Social (IPHES-CERCA)","place":["Tarragona, Spain"]},{"name":"Departament d\u2019Hist\u00f2ria i Hist\u00f2ria de l\u2019Art, Universitat Rovira i Virgili","place":["Tarragona, Spain"]},{"name":"Deutsche Forschungsgemeinschaft Center for Advanced Studies \u201cWords, Bones, Genes, Tools\u201d, Department of Geosciences, University of T\u00fcbingen","place":["T\u00fcbingen, Germany"]},{"name":"Department of Physics and Geology, University of Perugia","place":["Perugia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2884-7118","authenticated-orcid":false,"given":"Antonio","family":"Profico","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5706-293X","authenticated-orcid":false,"given":"Carlos","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 de Paleoecologia Humana i Evoluci\u00f3 Social (IPHES-CERCA)","place":["Tarragona, Spain"]},{"name":"Departament d\u2019Hist\u00f2ria i Hist\u00f2ria de l\u2019Art, Universitat Rovira i Virgili","place":["Tarragona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-1371","authenticated-orcid":false,"given":"Giorgio","family":"Manzi","sequence":"additional","affiliation":[{"name":"Department of Environmental Biology, Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.quascirev.2024.108833"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04644-1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/qua.2023.70"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhevol.2015.02.007"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10852"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpp.2018.10.009"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpp.2020.10.002"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/joa.13813"},{"key":"e_1_3_4_9_2","first-page":"141","article-title":"The evolution, form and function of the human respiratory system","volume":"100","author":"Bastir M.","year":"2022","unstructured":"M. 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