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TREM1 enhances microglial plasticity through the spleen associated tyrosine kinase-Pyruvate dehydrogenase kinase-signal transducer and activator of transcription 3 (SYK-PDK-STAT3) signaling axis, ultimately promoting an immune environment favorable to tumor progression. ZIP4 depletion or TREM1 inhibition attenuates tumor growth and behavioral effects in vivo by disrupting the tumor\u2013microglia interaction. These findings establish ZIP4 as a key modulator of the GBM immune landscape and suggest a promising therapeutic target to counteract microglia-mediated tumor progression.<\/jats:p>","DOI":"10.1073\/pnas.2427073122","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T19:29:01Z","timestamp":1746041341000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":19,"title":["A zinc transporter drives glioblastoma progression via extracellular vesicles-reprogrammed microglial plasticity"],"prefix":"10.1073","volume":"122","author":[{"given":"Liyang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medicine, The University of Oklahoma Health Sciences Center","place":["Oklahoma City"]},{"name":"Department of Surgery, The University of Oklahoma Health Sciences Center","place":["Oklahoma City"]},{"name":"Department of Neurosurgery, Xiangya Hospital, Central South 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