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This strategy results in neuronal maturation and initiates downstream pathways distinct from the ones triggered by retinoic acid, the differentiation-inducing agent currently used in clinical practice for NB. Notably, both\n                    <jats:italic toggle=\"yes\">PRDX6<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">GSTP1<\/jats:italic>\n                    are highly expressed in the developing murine adrenal gland, as well as in high-risk,\n                    <jats:italic toggle=\"yes\">MYCN<\/jats:italic>\n                    -amplified NB, correlating with an undifferentiated state and poor prognosis. Together, our results provide insights into the potential of PRDX6 and GSTP1 as therapeutic targets for differentiation induction for children with NB.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2427211122","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T13:37:51Z","timestamp":1750253871000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":6,"title":["Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-4750","authenticated-orcid":false,"given":"Judit","family":"Lia\u00f1o-Pons","sequence":"first","affiliation":[{"name":"Department of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institutet","place":["Stockholm, 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