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The HOXB13\/SMARCD2 interaction alters chromatin accessibility at HOXB13-binding sites, causing increased proliferation in AR-negative PCa. Overall, this work demonstrates a distinct mechanism of action for HOXB13 and highlights its critical role in AR-negative castration-resistant PCa.<\/jats:p>","DOI":"10.1073\/pnas.2500327122","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T19:11:27Z","timestamp":1764875487000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":7,"title":["Distinct transcription factor interactions drive HOXB13 activity in different stages of prostate cancer"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-3427","authenticated-orcid":false,"given":"Betul","family":"Ersoy-Fazlioglu","sequence":"first","affiliation":[{"name":"Ko\u00e7 University Research Center for Translational Medicine","place":["Istanbul, T\u00fcrkiye"]},{"name":"Department of Medical Pharmacology, School of Medicine, Ko\u00e7 University","place":["Istanbul, 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