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We show that Drospondin is expressed in glial cells and is crucial for MB development. Our results also show that Drospondin genetically interacts with LpRs and that human Reelin rescues neuronal and brain structural defects in Drospondin-deficient flies. Furthermore, Drospondin-deficient flies exhibit altered sleep, locomotion, and social behaviors. Our results reveal that Drospondin is a\n                    <jats:italic toggle=\"yes\">Drosophila<\/jats:italic>\n                    protein with similar functions to mammalian Reelin\/F-spondin, that has an essential role in brain development and function, the impairment of which has profound functional consequences for the animal.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2502307123","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T16:58:41Z","timestamp":1769619521000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Drospondin, a glial glycoprotein with similarities to human Reelin\/F-spondin, contributes to\n                    <i>Drosophila<\/i>\n                    brain development and 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