{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T04:45:07Z","timestamp":1792903507500,"version":"4.5.0"},"reference-count":12,"publisher":"National Academy of Sciences","issue":"26","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000771","name":"Prostate Cancer UK","doi-asserted-by":"publisher","award":["PA14-012"],"award-info":[{"award-number":["PA14-012"]}],"id":[{"id":"10.13039\/501100000771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR | NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203312"],"award-info":[{"award-number":["NIHR203312"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>\n                    Cribriform prostate cancer (crPCa) is associated with poor clinical outcomes, yet its accurate detection remains challenging due to the poor sensitivity of standard-of-care diagnostic tools. Here, we use untargeted spatial metabolomics to identify fatty acid biosynthesis as a key metabolic pathway enriched in crPCa epithelium. We also show that imaging tumor lipid metabolism using [1-\n                    <jats:sup>11<\/jats:sup>\n                    C]acetate PET\/CT and proton magnetic resonance spectroscopy differentiates cribriform from noncribriform intermediate-risk prostate cancers in two prospective patient cohorts. These findings support the feasibility of using clinical metabolic imaging techniques as adjunctive tools for improving crPCa detection in clinical practice, with prospective studies in larger cohorts warranted to obtain definitive results.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2502423122","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T15:00:38Z","timestamp":1750690838000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["Spatial metabolomics informs the use of clinical imaging for improved detection of cribriform prostate cancer"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-9714","authenticated-orcid":false,"given":"Nikita","family":"Sushentsev","sequence":"first","affiliation":[{"name":"Department of Radiology, Addenbrooke\u2019s Hospital and University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Hamm","sequence":"additional","affiliation":[{"name":"Integrated BioAnalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-6626","authenticated-orcid":false,"given":"Roido","family":"Manavaki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke\u2019s Hospital and University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"McLean","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke\u2019s Hospital and University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Birchall","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke\u2019s Hospital and University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-3197","authenticated-orcid":false,"given":"Dmitry","family":"Soloviev","sequence":"additional","affiliation":[{"name":"Lewis Group, School of Cancer Sciences, University of Glasgow","place":["Glasgow, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Lewis Group, School of Cancer Sciences, University of Glasgow","place":["Glasgow, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7452-4961","authenticated-orcid":false,"given":"Luigi","family":"Aloj","sequence":"additional","affiliation":[{"name":"Department of Radiology, Addenbrooke\u2019s Hospital and University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Flint","sequence":"additional","affiliation":[{"name":"Integrated BioAnalysis, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandr","family":"Zakirov","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, University of Cambridge","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-5083","authenticated-orcid":false,"given":"Ian G.","family":"Mills","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgical Sciences, University of Oxford","place":["Oxford, United Kingdom"]},{"name":"Prostate Cancer Centre of Excellence, Patrick G. Johnston Centre for Cancer Research, Queen\u2019s University Belfast","place":["Belfast, United Kingdom"]},{"name":"Department of Biomedicine, Aarhus University","place":["Aarhus, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent J.","family":"Gnanapragasam","sequence":"additional","affiliation":[{"name":"Department of Urology, Cambridge University Hospitals National Health Service Foundation Trust","place":["Cambridge, United Kingdom"]},{"name":"Cambridge Urology Translational Research and Clinical Trials Office, Addenbrooke\u2019s Hospital","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Y.","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cambridge University Hospitals National Health Service Foundation Trust","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon T.","family":"Barry","sequence":"additional","affiliation":[{"name":"Bioscience, Discovery, Oncology Research and Development, AstraZeneca","place":["Cambridge, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5699-8488","authenticated-orcid":false,"given":"Richard J. 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