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ImmZIKV is particularly sensitive to structural distortion by Fab A9E. The primary mode of infection used by ImmZIKV is via antibody-dependent enhancement of infection (ADE)\u2014the formation of virus complex with nonneutralizing or subneutralizing concentrations of antibodies, that leads to enhanced infection of Fc\u03b3 positive myeloid cells. IgG A9E, by itself displays poor ADE activity. When IgG LALA mutant or Fab A9E is added to other enhancing antibody (DV62.5):virus complexes, they can strongly reduce the overall ADE activity. This is likely due to their ability to distort virus particle structure, suggesting that HMAb A9E could be a potential prophylactic and therapeutic candidate against all maturation states of ZIKV.<\/jats:p>","DOI":"10.1073\/pnas.2502522122","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T13:38:01Z","timestamp":1766583481000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["An ultrapotent human antibody neutralizes all maturation states of Zika virus"],"prefix":"10.1073","volume":"122","author":[{"given":"Bo","family":"Shu","sequence":"first","affiliation":[{"name":"Program in Emerging Infectious Diseases, Duke-National University of Singapore Medical School","place":["Singapore, Singapore"]},{"name":"Department of Biological Sciences, National University of Singapore","place":["Singapore, 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