{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:48:41Z","timestamp":1787496521240,"version":"build-2736575974"},"reference-count":53,"publisher":"National Academy of Sciences","issue":"37","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI096528"],"award-info":[{"award-number":["AI096528"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","award":["AI112949"],"award-info":[{"award-number":["AI112949"]}],"id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:p>\n                    Hydrogen sulfide production is a characteristic that distinguishes\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    serovars from closely related species, such as\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    , but its biological significance remains obscure. Here, we show that PhsABC and AsrABC-mediated hydrogen sulfide production by\n                    <jats:italic toggle=\"yes\">Salmonella enterica<\/jats:italic>\n                    serovar (\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    ) Typhimurium was linked to an increased abundance of\n                    <jats:italic toggle=\"yes\">Deltaproteobacteria<\/jats:italic>\n                    and inhibition of cytochrome\n                    <jats:italic toggle=\"yes\">bd<\/jats:italic>\n                    oxidase-mediated aerobic respiration of\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    in the murine large intestine. Functional\n                    <jats:italic toggle=\"yes\">phsABC<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">asrABC<\/jats:italic>\n                    operons provided a growth benefit to\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    Typhimurium in the cecum of\n                    <jats:italic toggle=\"yes\">Enterobacterales-<\/jats:italic>\n                    free conventional mice only upon inoculation with commensal\n                    <jats:italic toggle=\"yes\">E. coli.<\/jats:italic>\n                    In gnotobiotic mice engrafted with a defined community of 17 human\n                    <jats:italic toggle=\"yes\">Clostridia<\/jats:italic>\n                    isolates,\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    Typhimurium infection inhibited cytochrome\n                    <jats:italic toggle=\"yes\">bd<\/jats:italic>\n                    oxidase-mediated aerobic respiration in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    only in the presence of\n                    <jats:italic toggle=\"yes\">Desulfovibrio piger<\/jats:italic>\n                    , a sulfide-producing representative of the\n                    <jats:italic toggle=\"yes\">Deltaproteobacteria.<\/jats:italic>\n                    A\n                    <jats:italic toggle=\"yes\">S.<\/jats:italic>\n                    Typhimurium strain deficient for hydrogen sulfide production (\n                    <jats:italic toggle=\"yes\">phsA asrA<\/jats:italic>\n                    mutant) did not inhibit cytochrome\n                    <jats:italic toggle=\"yes\">bd<\/jats:italic>\n                    oxidase-mediated aerobic respiration in\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , even when\n                    <jats:italic toggle=\"yes\">D. piger<\/jats:italic>\n                    was present. Collectively, these data suggest that the\n                    <jats:italic toggle=\"yes\">phsABC<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">asrABC<\/jats:italic>\n                    operons of\n                    <jats:italic toggle=\"yes\">Salmonella<\/jats:italic>\n                    serovars provide a benefit during competition with closely related bacteria, such as\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    , by inhibiting cytochrome\n                    <jats:italic toggle=\"yes\">bd<\/jats:italic>\n                    oxidase-mediated aerobic respiration of the commensal.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2504095122","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T16:14:07Z","timestamp":1757693647000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":7,"title":["<i>Salmonella<\/i>\n                    produces sulfide to compete with\n                    <i>Escherichia coli<\/i>\n                    in the gut lumen"],"prefix":"10.1073","volume":"122","author":[{"given":"Ana\u00efs B.","family":"Larabi","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor R.","family":"Tiffany","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo L. P.","family":"Masson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli J.","family":"Bejarano","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Liou","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Radlinski","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore M.","family":"Demars","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9131-6657","authenticated-orcid":false,"given":"Ren\u00e9e M.","family":"Tsolis","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-7809","authenticated-orcid":false,"given":"Andreas J.","family":"B\u00e4umler","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, School of Medicine, University of California","place":["Davis"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400009220"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400010743"},{"key":"e_1_3_4_3_2","first-page":"217","article-title":"The isolation of typhoid bacilli from urine and feces with the description of a new double sugar tube medium","volume":"25","author":"Russell F. 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