{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:59:44Z","timestamp":1789797584736,"version":"4.0.1"},"reference-count":69,"publisher":"National Academy of Sciences","issue":"30","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009726","name":"Foundation for Angelman Syndrome Therapeutics","doi-asserted-by":"publisher","award":["M1500428"],"award-info":[{"award-number":["M1500428"]}],"id":[{"id":"10.13039\/100009726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009726","name":"Foundation for Angelman Syndrome Therapeutics","doi-asserted-by":"publisher","award":["M2000491 M1302631"],"award-info":[{"award-number":["M2000491 M1302631"]}],"id":[{"id":"10.13039\/100009726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,7,29]]},"abstract":"<jats:p>\n                    Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A (\n                    <jats:italic toggle=\"yes\">UBE3A<\/jats:italic>\n                    ) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic development. Here, we show that pigs (\n                    <jats:italic toggle=\"yes\">Sus scrofa<\/jats:italic>\n                    ) with a maternally inherited deletion of\n                    <jats:italic toggle=\"yes\">UBE3A<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">UBE3A<\/jats:italic>\n                    <jats:sup>-\/+<\/jats:sup>\n                    ) have altered postnatal behaviors, impaired vocalizations, reduced brain growth, motor incoordination, and ataxia. Neonatal\n                    <jats:italic toggle=\"yes\">UBE3A<\/jats:italic>\n                    <jats:sup>-\/+<\/jats:sup>\n                    pigs exhibited several symptoms observed in infants with Angelman syndrome, including hypotonia, suckling deficits, and failure to thrive. Collectively, these findings are consistent with the pathophysiology and developmental trajectory observed in individuals with Angelman syndrome. We anticipate that this pig model will advance our understanding of the pathophysiology of Angelman syndrome and be used as a preclinical large animal model for therapeutic development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2505152122","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T19:13:17Z","timestamp":1753125197000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":9,"title":["A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8554-0994","authenticated-orcid":false,"given":"Luke S.","family":"Myers","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University","place":["College Station"]},{"name":"Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey","place":["Guildford, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-4531","authenticated-orcid":false,"given":"Sarah G.","family":"Christian","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University","place":["College Station"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University","place":["Raleigh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0949-2163","authenticated-orcid":false,"given":"Renan","family":"Sper","sequence":"additional","affiliation":[{"name":"Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University","place":["Raleigh"]},{"name":"Comparative Medicine Institute, North Carolina State University","place":["Raleigh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University","place":["College Station"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1890-2400","authenticated-orcid":false,"given":"Laura","family":"Montes","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University","place":["College Station"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B. 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