{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:16:16Z","timestamp":1785816976597,"version":"3.56.0"},"reference-count":72,"publisher":"National Academy of Sciences","issue":"46","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EO1002"],"award-info":[{"award-number":["01EO1002"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["210879364"],"award-info":[{"award-number":["210879364"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R00DE026856"],"award-info":[{"award-number":["R00DE026856"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R01DE031382"],"award-info":[{"award-number":["R01DE031382"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["113N15716"],"award-info":[{"award-number":["113N15716"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13N15705"],"award-info":[{"award-number":["13N15705"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2051 - Project-ID 390713860"],"award-info":[{"award-number":["EXC 2051 - Project-ID 390713860"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:p>\n                    The fungus\n                    <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                    and the Gram-positive bacterium\n                    <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                    share mucosal niches in the human body. As opportunistic pathogens, both are found to expand population size during dysbiosis, and can cause severe systemic infections in susceptible individuals. Here, we show that the presence of\n                    <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                    results in increased host cell damage by\n                    <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                    . Furthermore,\n                    <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                    aggravates oropharyngeal candidiasis in mice. Increased damage is mediated by enterococcal cytolysin, and involves both physical interaction and altered glucose availability. Physical interaction promotes accumulation of bacteria on host cells, facilitating contact of cytolysin with host cells. Glucose depletion by the metabolic activity of the fungus sensitized host cells to cytolysin. This work illustrates how a complex interplay between fungi and bacteria can result in detrimental consequences for the host.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2505310122","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:03:22Z","timestamp":1762805002000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":9,"title":["Synergistic interactions between\n                    <i>Candida albicans<\/i>\n                    and\n                    <i>Enterococcus faecalis<\/i>\n                    promote toxin-dependent host cell damage"],"prefix":"10.1073","volume":"122","author":[{"given":"Mario","family":"Kapitan","sequence":"first","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]},{"name":"Center for Sepsis Control and Care, University Hospital Jena","place":["Jena, Germany"]},{"name":"Friedrich-Schiller-University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Joanna","family":"Niemiec","sequence":"additional","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]},{"name":"Center for Sepsis Control and Care, University Hospital Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-7153","authenticated-orcid":false,"given":"Nicolas","family":"Millet","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Harbor-UCLA Medical Center","place":["Torrance"]},{"name":"Institute for Infection and Immunity, Lundquist Institute at Harbor-UCLA Medical Center","place":["Torrance"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4345-3432","authenticated-orcid":false,"given":"Philipp","family":"Brandt","sequence":"additional","affiliation":[{"name":"Friedrich-Schiller-University Jena","place":["Jena, Germany"]},{"name":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Estiak Khan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]},{"name":"Friedrich-Schiller-University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-7020","authenticated-orcid":false,"given":"Anna","family":"Czapka","sequence":"additional","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketema","family":"Abdissa","sequence":"additional","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Research Group MALDI Imaging, Innovative Biophotonics, Department of Othorhynolaryngology, University Hospital Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lange","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hygiene, University of T\u00fcbingen","place":["T\u00fcbingen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Veleba","sequence":"additional","affiliation":[{"name":"Singapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University","place":["Singapore, Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandor","family":"Nietzsche","sequence":"additional","affiliation":[{"name":"Center for Electron Microscopy, University Hospital Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5687-2444","authenticated-orcid":false,"given":"Alexander S.","family":"Mosig","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry II, University Hospital Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"L\u00f6ffler","sequence":"additional","affiliation":[{"name":"Center for Sepsis Control and Care, University Hospital Jena","place":["Jena, Germany"]},{"name":"Department of Medical Microbiology, University Hospital Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Marquet","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases and Infection Control, Jena University Hospital","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Makarewicz","sequence":"additional","affiliation":[{"name":"Institute for Infectious Diseases and Infection Control, Jena University Hospital","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5472-3074","authenticated-orcid":false,"given":"Kimberly A.","family":"Kline","sequence":"additional","affiliation":[{"name":"Singapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University","place":["Singapore, Singapore"]},{"name":"Department of Microbiology and Molecular Medicine, University of Geneva","place":["Geneva, Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slavena","family":"Vylkova","sequence":"additional","affiliation":[{"name":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology\u2013Hans Kn\u00f6ll Institute","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-6267","authenticated-orcid":false,"given":"Marc","family":"Swidergall","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Harbor-UCLA Medical Center","place":["Torrance"]},{"name":"Institute for Infection and Immunity, Lundquist Institute at Harbor-UCLA Medical Center","place":["Torrance"]},{"name":"David Geffen School of Medicine at University of California, Los Angeles","place":["Los Angeles, CA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6033-9984","authenticated-orcid":false,"given":"Ilse D.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Kn\u00f6ll Institute","place":["Jena, Germany"]},{"name":"Friedrich-Schiller-University Jena","place":["Jena, Germany"]},{"name":"Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.013"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/376906"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1997.5110"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05162-11"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00449-12"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00780-19"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/am.11.2.136-140.1963"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.12.1182"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/15.1.49"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/591861"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1099\/00222615-23-1-45"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.UTI-0012-2012"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep02191"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01937-21"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007717"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.1999.00519.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.07.001"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31816591be"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.26040"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111771"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2021.10.013"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00177-21"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000139107"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature00802"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.026385-0"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1103996"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191378698"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.8.1626"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.158.3.777-783.1984"},{"key":"e_1_3_4_30_2","first-page":"9","article-title":"Evaluation of therapeutic measures for treating endophthalmitis caused by isogenic toxin-producing and toxin-nonproducing Enterococcus faecalis strains","volume":"36","author":"Jett B. D.","year":"1995","unstructured":"B. D. Jett, H. G. Jensen, R. V. Atkuri, M. S. Gilmore, Evaluation of therapeutic measures for treating endophthalmitis caused by isogenic toxin-producing and toxin-nonproducing Enterococcus faecalis strains. Invest. Ophthalmol. Vis. Sci. 36, 9\u201315 (1995).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.6.2445-2452.1992"},{"key":"e_1_3_4_32_2","first-page":"1534","article-title":"Enterococcus faecalis from food, clinical specimens, and oral sites: Prevalence of virulence factors in association with biofilm formation","volume":"6","author":"Anderson A. C.","year":"2015","unstructured":"A. C. Anderson , Enterococcus faecalis from food, clinical specimens, and oral sites: Prevalence of virulence factors in association with biofilm formation. Front. Microbiol. 6, 1534 (2015).","journal-title":"Front. Microbiol."},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.3402\/jom.v4i0.10855"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00914-12"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620432114"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84429"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.8.3473-3481.1987"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.172.1.155-163.1990"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.17.5369"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.1.25-30.1992"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.10.6044-6047.2000"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1086\/338836"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01412.x"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1996.831449.x"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700390207"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom10020247"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.96.6.1895-1902.1968"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00438-003-0819-1"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00910-19"},{"key":"e_1_3_4_50_2","article-title":"Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans","volume":"23","author":"Mogavero S.","year":"2021","unstructured":"S. Mogavero , Candidalysin delivery to the invasion pocket is critical for host epithelial damage induced by Candida albicans. Cell Microbiol. 23, e13378 (2021).","journal-title":"Cell Microbiol."},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009221"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/415084a"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2009.07.004"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700390207"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05896-11"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.062109-0"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00310.x"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4226com"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.12.004"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.177"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.019"},{"key":"e_1_3_4_62_2","volume-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection","author":"Garsin D. A.","year":"2014","unstructured":"D. A. Garsin , \u201cPathogenesis and Models of Enterococcal Infection\u201d in Enterococci: From Commensals to Leading Causes of Drug Resistant Infection, M. S. Gilmore, D. B. Clewell, Y. Ike, N. Shankar, Eds. (Massachusetts Eye and Ear Infirmary, Boston, 2014)."},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.07.003"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.12.3.423"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2010.02131.x"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.555363"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.011"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0059-5"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00025-17"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-00837-0"},{"key":"e_1_3_4_71_2","unstructured":"M. Veleba A. Lange I. D. Jacobsen Dataset Open Enterococcus faecalis genome sequences_illumina sequencing [Data set]. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.17433767. Deposited 24 October 2025."},{"key":"e_1_3_4_72_2","unstructured":"M. Marquet I. D. Jacobsen O. Makarewicz Enterococcus faecalis genome sequences_nanopore sequencing [Data set]. Zenodo. https:\/\/doi.org\/10.5281\/zenodo.17432831. Deposited 24 October 2025."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2505310122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:03:58Z","timestamp":1762805038000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2505310122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,10]]},"references-count":72,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2025,11,18]]}},"alternative-id":["10.1073\/pnas.2505310122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2505310122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,10]]},"assertion":[{"value":"2025-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2505310122"}}