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Importantly, inhibition of type I interferon signaling or the RIG-I sensing pathway abrogated the antiviral activity of HIF. Moreover, daprodustat increased interferon signaling in response to viral RNA, suggesting that HIF inhibits pneumovirus replication through enhancing viral RNA sensing. Mechanistically, daprodustat reduced N\n                    <jats:sup>6<\/jats:sup>\n                    -methyladenosine modification of viral RNA through upregulation of RNA demethylases, promoting detection by innate immune sensors. This study highlights the intricate interplay between hypoxia and antiviral immunity and offers valuable insights into pneumovirus\u2013host interactions and potential therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2506647123","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T16:16:01Z","timestamp":1775578561000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":2,"title":["Hypoxia inducible factors regulate pneumovirus replication by enhancing innate immune sensing"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1968-211X","authenticated-orcid":false,"given":"Jiyeon","family":"Ha","sequence":"first","affiliation":[{"name":"CAMS Oxford Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, Nuffield Department of Medicine, University of Oxford","place":["Oxford, United 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