{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:04:05Z","timestamp":1792623845405,"version":"4.5.0"},"reference-count":67,"publisher":"National Academy of Sciences","issue":"44","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI029564"],"award-info":[{"award-number":["AI029564"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE032830"],"award-info":[{"award-number":["DE032830"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE027087"],"award-info":[{"award-number":["DE027087"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE0234804"],"award-info":[{"award-number":["DE0234804"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE029625"],"award-info":[{"award-number":["DE029625"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"HHS | NIH | National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["DE029200"],"award-info":[{"award-number":["DE029200"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI153265"],"award-info":[{"award-number":["AI153265"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI158314"],"award-info":[{"award-number":["AI158314"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI067798"],"award-info":[{"award-number":["AI067798"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007316","name":"HHS | NIH | NCI | Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["CA232109"],"award-info":[{"award-number":["CA232109"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002489"],"award-info":[{"award-number":["UL1TR002489"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002489-03S2"],"award-info":[{"award-number":["UL1TR002489-03S2"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201700001I"],"award-info":[{"award-number":["HHSN268201700001I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201700002I"],"award-info":[{"award-number":["HHSN268201700002I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201700003I"],"award-info":[{"award-number":["HHSN268201700003I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201700004I"],"award-info":[{"award-number":["HHSN268201700004I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201700005I"],"award-info":[{"award-number":["HHSN268201700005I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:p>Inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1\u03b2). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanism(s) of this sex bias is unknown. This study explored whether enhanced inflammasome represents a causal mechanism for this bias. Analyses of three separate human studies (&gt;6,200 samples) show that males have significantly higher IL-1\u03b2 in the gingival crevicular fluid than females during health and periodontitis. This pattern is experimentally reproduced with different versions of the ligature-induced periodontitis mouse model where males show greater IL-1\u03b2 secretion than females. The inflammasome drives bone resorption in males but not females as revealed by analyses of inflammasome gene-deletion mice. Pharmacologic treatment with a caspase-1\/4 inhibitor reduces inflammatory cell infiltration, dampens osteoclastogenesis signaling (via the receptor activator of nuclear factor-kappa B pathway), and prevents bone resorption in males but not females during experimental periodontitis. While ovariectomized females show no change in their nonresponsiveness to caspase-1\/4 inhibition, orchiectomized males no longer respond to the inhibition, suggesting the importance of an intact male reproductive system in the mediation of this inhibition. Thus, our study identifies inflammasome activation as causal for male-biased experimental periodontitis and supports sex-stratified studies to foster future advancement of inflammasome therapeutics in periodontics.<\/jats:p>","DOI":"10.1073\/pnas.2507092122","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:06:01Z","timestamp":1761591961000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["Inflammasome targeting for periodontitis prevention is sex dependent"],"prefix":"10.1073","volume":"122","author":[{"given":"Tomaz","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-0599","authenticated-orcid":false,"given":"Karen V.","family":"Swanson","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, School of Medicine, University of North Carolina","place":["Chapel Hill"]},{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa S.","family":"Girnary","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-7698","authenticated-orcid":false,"given":"Marcelo","family":"Freire","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego","place":["La Jolla"]},{"name":"Department of Genomic Medicine and Infectious Diseases, J. Craig Venter Institute","place":["La Jolla"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Moss","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Health Data Science, School of Medicine, University of Indiana","place":["Indianapolis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-7251","authenticated-orcid":false,"given":"Kimon","family":"Divaris","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pollyana Coelho Pessoa","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6503-539X","authenticated-orcid":false,"given":"W. June","family":"Brickey","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill"]},{"name":"Department of Microbiology and Immunology, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5828-9359","authenticated-orcid":false,"given":"John A.","family":"Wrobel","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill"]},{"name":"Department of Biochemistry and Biophysics, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi Yeigi","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manaal","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Morelli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Seaman","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research, National Institutes of Health","place":["Bethesda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Preisser","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Preisser","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Makhanova","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Susin","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishma P.","family":"Vias","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Styner","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, School of Medicine, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Periodontics Department, College of Dentistry, University of Iowa","place":["Iowa City"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Queiroz","family":"Pirih","sequence":"additional","affiliation":[{"name":"Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California Los Angeles","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Regenerative and Reconstructive Sciences, School of Dentistry, University of California Los Angeles","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvinder Singh","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, North Carolina State University","place":["Raleigh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6388-2491","authenticated-orcid":false,"given":"Adam D.","family":"Lietzan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Webster-Cyriaque","sequence":"additional","affiliation":[{"name":"National Institute of Dental and Craniofacial Research, National Institutes of Health","place":["Bethesda"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-0395","authenticated-orcid":false,"given":"Jenny P. Y.","family":"Ting","sequence":"additional","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, University of North Carolina","place":["Chapel Hill"]},{"name":"Department of Microbiology and Immunology, University of North Carolina","place":["Chapel Hill"]},{"name":"Department of Genetics, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0610-3193","authenticated-orcid":false,"given":"Julie T.","family":"Marchesan","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontics, and Dental Hygiene, Adams School of Dentistry, University of North Carolina","place":["Chapel Hill"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034512457373"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12323"},{"issue":"1","key":"e_1_3_4_3_2","first-page":"S74","article-title":"Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"89","author":"Chapple I. L. C.","year":"2018","unstructured":"I. L. C. Chapple , Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World workshop on the classification of periodontal and peri-implant diseases and conditions. J. Periodontol. 89 (suppl. 1), S74\u2013S84 (2018).","journal-title":"J. Periodontol."},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519846113"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01487.x"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12782"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12765"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2017.00189"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518759915"},{"key":"e_1_3_4_11_2","first-page":"CD012018","article-title":"Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries","volume":"4","author":"Worthington H. V.","year":"2019","unstructured":"H. V. Worthington , Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental caries. Cochrane Database Syst. Rev. 4, CD012018 (2019).","journal-title":"Cochrane Database Syst. Rev."},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/cdoe.12128"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520916151"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00787-w"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.90"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01057.x"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1990.tb01038.x"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140180"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12621"},{"key":"e_1_3_4_20_2","first-page":"cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber A.","year":"2010","unstructured":"A. Weber, P. Wasiliew, M. Kracht, Interleukin-1 (IL-1) pathway. Sci. Signal. 3, cm1 (2010).","journal-title":"Sci. Signal."},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.4.1984"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13576"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1471"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12269"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18405-9"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.05.002"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171749"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209171109"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12910"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.05.013"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.88183.3"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160379"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.111344"},{"key":"e_1_3_4_35_2","first-page":"111","article-title":"Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced arthritis in mice","volume":"34","author":"Zhang Y.","year":"2016","unstructured":"Y. Zhang, Y. Zheng, Effects and mechanisms of potent caspase-1 inhibitor VX765 treatment on collagen-induced arthritis in mice. Clin. Exp. Rheumatol. 34, 111\u2013118 (2016).","journal-title":"Clin. Exp. Rheumatol."},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S507269"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.213"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.018"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21331"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0035-4"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.01.001"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64685-y"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01618-13"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.160.1.403"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw069"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-28524-1_13"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900532"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00679"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05940-9"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211009767"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0668"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100258"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-340281"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601543"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-020-00301-y"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313863"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/509282a"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuad018"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007696"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612197"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2017.128"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2013.04.005"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.171311"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.01.004"},{"key":"e_1_3_4_66_2","unstructured":"D. W. Williams N. M. Moutsopoulos Single-cell atlas of human oral mucosa reveals a stromal-neutrophil axis in tissue immunity regulation. Gene Expression Omnibus (GEO). https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE164241. Accessed 14 April 2023."},{"key":"e_1_3_4_67_2","unstructured":"I. Nishimura T. Kondo Single Cell RNA sequencing of mouse periodontitis gingiva. Gene Expression Omnibus (GEO). https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE228635. Accessed 26 February 2025."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2507092122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:06:53Z","timestamp":1761592013000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2507092122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,27]]},"references-count":67,"journal-issue":{"issue":"44","published-print":{"date-parts":[[2025,11,4]]}},"alternative-id":["10.1073\/pnas.2507092122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2507092122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,27]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2507092122"}}