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Thus, in addition to connecting immune cells to target cells, the clinical promise of engagers results from their ability to manipulate the nanoscale architecture of the immune synapse.<\/jats:p>","DOI":"10.1073\/pnas.2507336122","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T17:53:16Z","timestamp":1758217996000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Nanoscale restructuring of the immune synapse with an engager enhances NK cell function"],"prefix":"10.1073","volume":"122","author":[{"given":"Khodor S.","family":"Hazime","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington","place":["London, United 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