{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:26:34Z","timestamp":1781105194974,"version":"3.54.1"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"17","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:p>\n                    Non\u2013small cell lung cancer (NSCLC) patients with tumors harboring\n                    <jats:italic toggle=\"yes\">STK11<\/jats:italic>\n                    mutations are resistant to standard of care anti-PD-1\/PD-L1 blockade. For this patient population there are no currently available tailored treatments, underlying the critical need to discover effective therapeutic strategies. In this study, we dissected the molecular mechanisms responsible for\n                    <jats:italic toggle=\"yes\">STK11<\/jats:italic>\n                    -mediated resistance to immune checkpoint blockade (ICB) and identified CRTC2, a coactivator of the transcription factor cAMP response element-binding protein (CREB), as a key signaling node regulating\n                    <jats:italic toggle=\"yes\">Stk11<\/jats:italic>\n                    -dependent cell-extrinsic functions. CRTC2 deletion remodeled the immune profiles of\n                    <jats:italic toggle=\"yes\">Stk11<\/jats:italic>\n                    -KO tumors and resensitized them to anti-PD-1 treatment, comparably to\n                    <jats:italic toggle=\"yes\">Stk11<\/jats:italic>\n                    -proficient tumors. Mechanistically, the abrogation of the binding between CRTC2 and CREB was sufficient to restore sensitivity to immunotherapy. These findings provide critical insights into the central role of CRTC2 in modulating response to ICB and identify the disruption of CRTC2\u2013CREB interaction as a potential therapeutic approach for this patient population.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2508762123","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T16:07:51Z","timestamp":1776874071000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":0,"title":["Targeting CRTC2 reverses\n                    <i>STK11<\/i>\n                    mutant NSCLC tumor resistance to immunotherapy"],"prefix":"10.1073","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4088-044X","authenticated-orcid":false,"given":"Dimitri","family":"Robay","sequence":"first","affiliation":[{"name":"Novartis Biomedical Research, Oncology","place":["Basel, 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