{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:57:50Z","timestamp":1787813870001,"version":"build-2784847793"},"reference-count":71,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["22-29928S"],"award-info":[{"award-number":["22-29928S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001824","name":"Czech Science Foundation","doi-asserted-by":"crossref","award":["19-12774S"],"award-info":[{"award-number":["19-12774S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ELIXIR-CZ","award":["LM2023055"],"award-info":[{"award-number":["LM2023055"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:p>\n                    One of the reproductive barriers between diverging populations during formation of a new species is the sterility of their hybrids. The\n                    <jats:italic toggle=\"yes\">Prdm9-<\/jats:italic>\n                    driven hybrid male sterility of\n                    <jats:italic toggle=\"yes\">Mus musculus musculus<\/jats:italic>\n                    \u00d7\n                    <jats:italic toggle=\"yes\">Mus musculus domesticus<\/jats:italic>\n                    hybrids depends on the interaction between PRDM9, a histone methyltransferase that determines the positions of meiotic recombination hotspots, and an as yet unknown X-linked genetic factor within the Hybrid sterility X2 (\n                    <jats:italic toggle=\"yes\">Hstx2<\/jats:italic>\n                    ) locus. Here, we report that the\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    microRNA (miRNA) gene cluster is the predicted\n                    <jats:italic toggle=\"yes\">Hstx2<\/jats:italic>\n                    hybrid sterility factor. We show that removal of the\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    genes restores the fertility of sterile hybrids and improves meiotic synapsis of homologous chromosomes.\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    knockout also restores spermatogenesis in sterile chromosomal translocation carriers, demonstrating that\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    acts as a meiotic checkpoint that can be activated independently of\n                    <jats:italic toggle=\"yes\">Prdm9<\/jats:italic>\n                    intersubspecific incompatibility. Furthermore, the\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    knockout increases the global recombination rate in hybrids and in parental\n                    <jats:italic toggle=\"yes\">Mus m. domesticus<\/jats:italic>\n                    mice. This demonstrates that\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    is responsible for the phenotypes of the two overlapping genetic loci, the\n                    <jats:italic toggle=\"yes\">Hstx2<\/jats:italic>\n                    engaged in fertility of hybrids and the Meiotic recombination 1 (\n                    <jats:italic toggle=\"yes\">Meir1<\/jats:italic>\n                    ) controlling the recombination rate. The finding of enlarged\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    clusters in all European\n                    <jats:italic toggle=\"yes\">Mus m. musculus<\/jats:italic>\n                    samples tested and the identification of differentially expressed targets suggest that the reproductive barrier between the two subspecies is sensitive to copy number variation of\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    genes. Together, the underdominant interaction between\n                    <jats:italic toggle=\"yes\">Prdm9<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">Mir465<\/jats:italic>\n                    provides a rare example of Dobzhansky\u2013Muller incompatibility in hybrids of closely related species, making it accessible for further analysis at the molecular level.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2510229122","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T18:11:50Z","timestamp":1759428710000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":9,"title":["Mouse X-linked microRNA cluster regulates the meiotic checkpoint and\n                    <i>Prdm9<\/i>\n                    -driven hybrid sterility in a copy number\u2013dependent manner"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1406-1707","authenticated-orcid":false,"given":"Petr","family":"Jansa","sequence":"first","affiliation":[{"name":"Laboratory of Mouse Molecular Genetics, Institute of Molecular Genetics, Czech Academy of Sciences","place":["Praha, Czech Republic"]},{"name":"Laboratory of Epigenetic Regulations, Institute of Molecular Genetics, Czech Academy of Sciences","place":["Praha, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1547-5530","authenticated-orcid":false,"given":"Giordano","family":"Tanieli","sequence":"additional","affiliation":[{"name":"Laboratory of Mouse Molecular Genetics, Institute of Molecular Genetics, Czech Academy of Sciences","place":["Praha, Czech Republic"]},{"name":"Laboratory of Epigenetic Regulations, Institute of Molecular Genetics, Czech Academy of Sciences","place":["Praha, Czech 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Transborder Medical Research Center, Institute of Medicine, University of Tsukuba","place":["Tsukuba, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4308-9626","authenticated-orcid":false,"given":"Kristian","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Evolutionary Biology","place":["Ploen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Odenthal-Hesse","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Evolutionary Biology","place":["Ploen, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-1169","authenticated-orcid":false,"given":"Jan","family":"Provaznik","sequence":"additional","affiliation":[{"name":"Genomics Core Facility, EMBL","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-2547","authenticated-orcid":false,"given":"Vladimir","family":"Benes","sequence":"additional","affiliation":[{"name":"Genomics Core Facility, EMBL","place":["Heidelberg, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Pfeiferova","sequence":"additional","affiliation":[{"name":"Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences","place":["Praha, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-1525","authenticated-orcid":false,"given":"Michal","family":"Kolar","sequence":"additional","affiliation":[{"name":"Laboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences","place":["Praha, Czech 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