{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:37:31Z","timestamp":1781109451384,"version":"3.54.1"},"reference-count":99,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Emerging key program of guangzhou laboratory, China","award":["EKPG22-30-6"],"award-info":[{"award-number":["EKPG22-30-6"]}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["75N93021C00016"],"award-info":[{"award-number":["75N93021C00016"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007204","name":"Vallee Foundation","doi-asserted-by":"publisher","award":["Vallee Scholars Program"],"award-info":[{"award-number":["Vallee Scholars Program"]}],"id":[{"id":"10.13039\/100007204","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005665","name":"Kinship Foundation","doi-asserted-by":"publisher","award":["Searle Scholars Program"],"award-info":[{"award-number":["Searle Scholars Program"]}],"id":[{"id":"10.13039\/100005665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"HHMI","doi-asserted-by":"publisher","award":["Emerging Pathogens Initiative"],"award-info":[{"award-number":["Emerging Pathogens Initiative"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:p>Antibody responses to the influenza virus hemagglutinin (HA) stem, a major target for broadly protective vaccine development, have been extensively characterized in humans. However, they remain largely elusive in other natural influenza hosts, including pigs, which are considered intermediate hosts for the emergence of pandemic strains. By leveraging single-cell variable, diversity, and joining (VDJ) sequencing, this study identified 25 porcine antibodies to the HA stem, including two cross-group bnAbs, 14-8 and 15-1, from vaccinated specific-pathogen-free pigs and unvaccinated domestic pigs. Cryogenic electron microscopy analysis showed that 14-8 targeted the well-characterized central stem epitope, whereas 15-1 bound to a linear epitope spanning the HA1\/HA2 junction. Additionally, while some porcine and human bnAbs targeted the central stem epitope via convergent molecular signatures, our results revealed a pig-specific recurring binding motif. Overall, our findings provide important insights into the commonalities and uniqueness of antibody responses between different species, which have significant implications for vaccine development for nonhuman animals.<\/jats:p>","DOI":"10.1073\/pnas.2510927122","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:10:52Z","timestamp":1759173052000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Molecular divergence and convergence of mammalian antibody responses to the influenza virus hemagglutinin stem"],"prefix":"10.1073","volume":"122","author":[{"given":"Huibin","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]},{"name":"Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi Wen","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]},{"name":"Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5347-1936","authenticated-orcid":false,"given":"Tossapol","family":"Pholcharee","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1702-3148","authenticated-orcid":false,"given":"Wenkan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawrab","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri","place":["Columbia"]},{"name":"Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri","place":["Columbia"]},{"name":"NextGen Center for Influenza and Emerging Infectious Diseases, University of Missouri","place":["Columbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2543-0042","authenticated-orcid":false,"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri","place":["Columbia"]},{"name":"Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri","place":["Columbia"]},{"name":"NextGen Center for Influenza and Emerging Infectious Diseases, University of Missouri","place":["Columbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshita B.","family":"Gopal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison R.","family":"Ardagh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunke","family":"Chen","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-7763","authenticated-orcid":false,"given":"Yuanxin","family":"Sun","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Wei","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-584X","authenticated-orcid":false,"given":"Walter N.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Host-Microbe Interactions, St. Jude Children\u2019s Research Hospital","place":["Memphis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Szlembarski","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danbi","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Gao","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona S. L.","family":"Fung","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxiu","family":"Xu","sequence":"additional","affiliation":[{"name":"Roy J. Carver Biotechnology Center, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4397-7132","authenticated-orcid":false,"given":"Richard J.","family":"Webby","sequence":"additional","affiliation":[{"name":"Department of Host-Microbe Interactions, St. Jude Children\u2019s Research Hospital","place":["Memphis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris K. P.","family":"Mok","sequence":"additional","affiliation":[{"name":"The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]},{"name":"Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]},{"name":"S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]},{"name":"School of Biomedical Sciences, The Chinese University of Hong Kong","place":["Hong Kong Special Administrative Region, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0395-9404","authenticated-orcid":false,"given":"Wenjun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri","place":["Columbia"]},{"name":"Department of Molecular Microbiology and Immunology, School of Medicine, University of Missouri","place":["Columbia"]},{"name":"NextGen Center for Influenza and Emerging Infectious Diseases, University of Missouri","place":["Columbia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9078-6697","authenticated-orcid":false,"given":"Nicholas C.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Illinois Urbana-Champaign","place":["Urbana"]},{"name":"Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign","place":["Urbana"]},{"name":"Center for Biophysics and Quantitative Biology, University of Illinois Urbana-Champaign","place":["Urbana"]},{"name":"Carle Illinois College of Medicine, University of Illinois Urbana-Champaign","place":["Urbana"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0002-y"},{"issue":"3","key":"e_1_3_4_2_2","first-page":"16","article-title":"Influenza: The once and future pandemic","volume":"125","author":"Taubenberger J. K.","year":"2010","unstructured":"J. K. Taubenberger, D. M. Morens, Influenza: The once and future pandemic. Public Health Rep. 125 (suppl. 3), 16\u201326 (2010).","journal-title":"Public Health Rep."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1353\/bhm.2002.0022"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2017.06.015"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/289366a0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81771-7"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.113553"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2017.0129"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038778"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1715471115"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7263"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.06.016"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029413"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1118-7"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ade4790"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ade4976"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08182"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1984-8"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00603-0"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.9.7367-7373.1998"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.044974-0"},{"key":"e_1_3_4_22_2","first-page":"158","article-title":"The pig as a mixing vessel for influenza viruses: Human and veterinary implications","volume":"3","author":"Ma W.","year":"2008","unstructured":"W. Ma, R. E. Kahn, J. A. Richt, The pig as a mixing vessel for influenza viruses: Human and veterinary implications. J. Mol. Genet. Med. 3, 158\u2013166 (2008).","journal-title":"J. Mol. Genet. Med."},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1189132"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40813-021-00196-0"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2020.198118"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038737"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1001\/jama.2024.24892","article-title":"First H5N1 bird flu infections in pigs raises concerns","volume":"333","author":"Anderer S.","year":"2025","unstructured":"S. Anderer, First H5N1 bird flu infections in pigs raises concerns. JAMA 333, 111 (2025).","journal-title":"JAMA"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02542-24","article-title":"Avian influenza A (H5N1) virus in dairy cattle: Origin, evolution, and cross-species transmission","volume":"15","author":"Mostafa A.","unstructured":"A. Mostafa , Avian influenza A (H5N1) virus in dairy cattle: Origin, evolution, and cross-species transmission. mBio 15, e0254224","journal-title":"mBio"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-024-01087-1"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1017\/S146625231000006X"},{"key":"e_1_3_4_31_2","first-page":"173","article-title":"Swine influenza virus vaccines: To change or not to change-that\u2019s the question","volume":"370","author":"Van Reeth K.","year":"2013","unstructured":"K. Van Reeth, W. Ma, Swine influenza virus vaccines: To change or not to change-that\u2019s the question. Curr. Top. Microbiol. Immunol. 370, 173\u2013200 (2013).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1336013"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0025-9"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-021-00417-1"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.04.009"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.073"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.043"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.09.010"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.07.022"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171491"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1205669"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222908"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adr8373"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1319058110"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204839"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1810927115"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04356-8"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009330"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-007-0270-2"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.11.001"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02810-18"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01388-13"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11414"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(75)90284-6"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(75)90285-8"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0966-842X(94)90123-6"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9716"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.08.084"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800708"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35236-y"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adt4147"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.06.003"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.662909"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.015"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe5449"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038349"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.08.006"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2501.181259"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-018-9420-1"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn838"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006366"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02284-17"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0463-x"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiae258"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2023.28.31.2300366"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3006.231459"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid3007.240508"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2415890"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08054-z"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1610.100508"},{"key":"e_1_3_4_81_2","unstructured":"H. Lv W. Liu N. C. Wu Influenza specific pig antibody. BioProject. https:\/\/www.ncbi.nlm.nih.gov\/bioproject\/PRJNA1174767. Deposited 18 October 2024."},{"key":"e_1_3_4_82_2","unstructured":"H. Lv W. Liu N. C. Wu Sequences of porcine antibodies. GenBank. https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/PQ821779. Deposited 1 January 2025."},{"key":"e_1_3_4_83_2","unstructured":"H. Lv W. Liu N. C. Wu Sequences of porcine antibodies. GenBank. https:\/\/www.ncbi.nlm.nih.gov\/nuccore\/PQ821838. Deposited 1 January 2025."},{"key":"e_1_3_4_84_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 14-1 in complex with influenza H1N1 A\/Solomon Island\/3\/2006 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48607. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtf\/pdb"},{"key":"e_1_3_4_85_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 14-2 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48608. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtg\/pdb"},{"key":"e_1_3_4_86_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 14-8 in complex with influenza H1N1 A\/Solomon Island\/3\/2006 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48609. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtf\/pdb"},{"key":"e_1_3_4_87_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 15-1 in complex with influenza H3N8 A\/Mallard\/Alberta\/362\/2017 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48610. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mti\/pdb"},{"key":"e_1_3_4_88_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 15-5 in complex with influenza H1N1 A\/Solomon Island\/3\/2006 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48611. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtj\/pdb"},{"key":"e_1_3_4_89_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 24-1G17 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48612. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtk\/pdb"},{"key":"e_1_3_4_90_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 24-1G23 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48613. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtl\/pdb"},{"key":"e_1_3_4_91_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 24-1G28 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-48614. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtm\/pdb"},{"key":"e_1_3_4_92_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 14-1 in complex with influenza H1N1 A\/Solomon Island\/3\/2006 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTF. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtf\/pdb"},{"key":"e_1_3_4_93_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 14-2 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTG. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtg\/pdb"},{"key":"e_1_3_4_94_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 14-8 in complex with influenza H1N1 A\/Solomon Island\/3\/2006 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTH. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mth\/pdb"},{"key":"e_1_3_4_95_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 15-1 in complex with influenza H3N8 A\/Mallard\/Alberta\/362\/2017 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTI. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mti\/pdb"},{"key":"e_1_3_4_96_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 15-5 in complex with influenza H1N1 A\/Solomon Island\/3\/2006 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTJ. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtj\/pdb"},{"key":"e_1_3_4_97_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 24-1G17 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTK. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtk\/pdb"},{"key":"e_1_3_4_98_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 24-1G23 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTL. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtl\/pdb"},{"key":"e_1_3_4_99_2","doi-asserted-by":"crossref","unstructured":"H. Lv T. Pholcharee N. C. Wu Structure of porcine Fab 24-1G28 in complex with influenza H1N1 A\/Hawaii\/70\/2019 hemagglutinin. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/9MTM. Deposited 11 January 2025.","DOI":"10.2210\/pdb9mtm\/pdb"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2510927122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T19:10:59Z","timestamp":1759173059000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2510927122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":99,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2025,10,7]]}},"alternative-id":["10.1073\/pnas.2510927122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2510927122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2510927122"}}