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Genetic deletion of Pycard\/Asc in\n                    <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                    mutant mice significantly reduced cyst formation, and kidney function was improved. Reductions were seen in inflammation, fibrosis, and urinary excretion of IL-18. Analogous results were obtained through tubule-specific inactivation of\n                    <jats:italic toggle=\"yes\">Pycard\/Asc<\/jats:italic>\n                    or treatment of\n                    <jats:italic toggle=\"yes\">Pkd1<\/jats:italic>\n                    mutant mice with the inflammasome inhibitor MCC950. These findings demonstrate that inflammasomes act as drivers of disease severity in an orthologous mouse model of ADPKD. We pinpoint a separate, epithelial pool of inflammasomes in the diseased kidney and identify inflammasome inhibition as a promising strategy for the treatment of ADPKD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2511204122","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T18:52:58Z","timestamp":1763059978000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of the inflammasome ameliorates orthologous polycystic kidney disease"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3440-3453","authenticated-orcid":false,"given":"Junwei","family":"Liu","sequence":"first","affiliation":[{"name":"Renal Department, Medical Center\u2014University of Freiburg","place":["Freiburg, Germany"]},{"name":"Faculty of Medicine, University of Freiburg","place":["Freiburg, 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