{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T19:01:25Z","timestamp":1785351685274,"version":"3.55.0"},"reference-count":18,"publisher":"National Academy of Sciences","issue":"27","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["91719305"],"award-info":[{"award-number":["91719305"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,7,8]]},"DOI":"10.1073\/pnas.2511399122","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T15:45:31Z","timestamp":1751298331000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["15-PGDH inhibition preserves blood\u2013brain barrier integrity and cognition"],"prefix":"10.1073","volume":"122","author":[{"given":"Daisy M.","family":"van Egmond","sequence":"first","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Amsterdam Neuroscience, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]},{"name":"Multiple Sclerosis Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Lygeroudi","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Amsterdam Neuroscience, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]},{"name":"Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9488-2918","authenticated-orcid":false,"given":"Gijs","family":"Kooij","sequence":"additional","affiliation":[{"name":"Department of Molecular Cell Biology and Immunology, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Amsterdam Neuroscience, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]},{"name":"Multiple Sclerosis Center Amsterdam, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.188"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2417224122"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2340"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abc8059"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108176"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.023"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.219519"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-025-02878-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02981-w"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2023.01.004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.620348"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.12.024"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36463-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.11.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165783"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04280-8"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2511399122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T15:45:39Z","timestamp":1751298339000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2511399122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":18,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2025,7,8]]}},"alternative-id":["10.1073\/pnas.2511399122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2511399122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]},"assertion":[{"value":"2025-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2511399122"}}