{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:49:49Z","timestamp":1784695789371,"version":"3.55.0"},"reference-count":73,"publisher":"National Academy of Sciences","issue":"45","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R21DA054281"],"award-info":[{"award-number":["R21DA054281"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA053558 (as trainee)"],"award-info":[{"award-number":["T32DA053558 (as trainee)"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"HHS | NIH | National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K99DA060948"],"award-info":[{"award-number":["K99DA060948"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,11,11]]},"abstract":"<jats:p>Drug-related memories can hinder abstinence goals in drug addiction. Promoting nondrugmemories via ventromedial prefrontal cortex (vmPFC)- and amygdala-guided extinctionyields mixed success. Postretrieval extinction (RE) destabilizes and updates memoriesduring reconsolidation, improving extinction. Supplementing RE, we tested methylphenidate(MPH), a dopamine agonist that promotes PFC-dependent learning and memory in cocaineuse disorder (CUD). In a proof-of-concept double-blind randomized clinical trialusing a within-subjects design, participants received oral MPH (20 mg) or placebobefore the retrieval of some of the conditioned stimuli (CS) (i.e., reminded CS+ vs.nonreminded CS+) followed by extinction; lab-simulated drug-seeking was measuredthe following day. Lower vmPFC activity following nonreminded CS+ (standardextinction) under placebo replicated the putative impairments in CUD; separately, RE (trend) and MPH conditions recruited the vmPFC, and RE\u2019s vmPFC-reliance correlatedwith drug-seeking only under placebo. Crucially, MPH-combined RE normalized cortico-limbicprocessing, bypassing the vmPFC and its amygdala connectivity. Pharmacologically-enhanced drug memory modulation may inform intervention development for addictionrecovery.<\/jats:p>","DOI":"10.1073\/pnas.2512310122","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:46:47Z","timestamp":1762278407000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-3990","authenticated-orcid":false,"given":"Ahmet O.","family":"Ceceli","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah G.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3441-9213","authenticated-orcid":false,"given":"K. Rachel","family":"Drury","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"McClain","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanthi S.","family":"Dassanayake","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey H.","family":"Newcorn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]},{"name":"Department of Pediatrics, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-7724","authenticated-orcid":false,"given":"Daniela","family":"Schiller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Alia-Klein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1680-229X","authenticated-orcid":false,"given":"Rita Z.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai","place":["New York"]},{"name":"Department of Neuroscience, Icahn School of Medicine at Mount Sinai","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-019-05074-8"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1105-1437"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2234"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14072"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.042"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01546-9"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.10.1642"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3119"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.03.048"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01153-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac366"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12545"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.15040433"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00014.x"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167975"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2017.04.006"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223006"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2013.12.010"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02666-1"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08637"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","unstructured":"D. Schiller J. W. Kanen J. E. LeDoux M.-H. Monfils E. A. Phelps Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement. Proc. Natl. Acad. Sci. U.S.A. 110 20040\u201320045 (2013).","DOI":"10.1073\/pnas.1320322110"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1215070"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.323"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00157"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3148"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2466-06.2006"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.08.007"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1054608"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511030103"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1723-08.2008"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.copsyc.2019.03.001"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2011.03.025"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2016.3907"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07249.x"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000118236"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2003.5.2\/rcasagrandetango"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68052032.x"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001507"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.07.004"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2506"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1101\/lm.024752.111"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-008-0105-x"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.03.027"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011455107"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.1129"},{"key":"e_1_3_4_46_2","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan D. V.","year":"1998","unstructured":"D. V. Sheehan , The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 22\u201333 (1998); quiz 34\u201357.","journal-title":"J. Clin. Psychiatry"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/0740-5472(92)90062-S"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220759"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac087"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.10.1325"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.02.015"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.11.001"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2012.00440.x"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(94)00234-7"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.0931"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00647"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-8119(03)00435-X"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602413113"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nss055"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4247-08.2009"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.6.3072"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.02.063"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301555"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00153.2004"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-23-10575.1999"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1535"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-25-08800.2003"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.09.009"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810650105"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1006\/nlme.2002.4099"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq6740"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10075"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.7.1173"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2512310122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T17:47:20Z","timestamp":1762278440000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2512310122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":73,"journal-issue":{"issue":"45","published-print":{"date-parts":[[2025,11,11]]}},"alternative-id":["10.1073\/pnas.2512310122"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2512310122","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2512310122"}}