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AEP and IGF2 contribute to PC by promoting osteoblast differentiation in heart tissue through integrin \u03b1v\u03b25 and IGF1R activation, respectively. Pharmacological blockade of integrin \u03b1v\u03b25 and IGF1R, especially when combined, effectively inhibits ectopic osteogenesis and disrupts the feedback loop between PC and cancer progression. 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