{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:01:49Z","timestamp":1791216109889,"version":"4.1.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"25","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,12,4]]},"abstract":"<jats:p>\n                    The mossy fiber-CA3 pyramidal neuron synapse is a main\n component of the hippocampal trisynaptic circuitry. Recent studies,\n however, suggested that inhibitory interneurons are the major targets\n of the mossy fiber system. To study the regulation of mossy\n fiber-interneuron excitation, we examined unitary and compound\n excitatory postsynaptic currents in dentate gyrus basket cells,\n evoked by paired recording between granule and basket cells or\n extracellular stimulation of mossy fiber collaterals. The application\n of an associative high-frequency stimulation paradigm induced\n posttetanic potentiation (PTP) followed by homosynaptic long-term\n potentiation (LTP). Analysis of numbers of failures, coefficient of\n variation, and paired-pulse modulation indicated that both PTP and LTP\n were expressed presynaptically. The Ca\n                    <jats:sup>2+<\/jats:sup>\n                    chelator\n 1,2-bis(2-aminophenoxy)ethane-\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2032,\n                    <jats:italic>N<\/jats:italic>\n                    \u2032-tetraacetic\n acid (BAPTA) did not affect PTP or LTP at a concentration of 10 mM but\n attenuated LTP at a concentration of 30 mM. Both forskolin, an adenylyl\n cyclase activator, and phorbolester diacetate, a protein kinase C\n stimulator, lead to a long-lasting increase in excitatory postsynaptic\n current amplitude. H-89, a protein kinase A inhibitor, and\n bisindolylmaleimide, a protein kinase C antagonist, reduced PTP,\n whereas only bisindolylmaleimide reduced LTP. These results may\n suggest a differential contribution of protein kinase A and C pathways\n to mossy fiber-interneuron plasticity. Interneuron PTP and LTP may\n provide mechanisms to maintain the balance between synaptic excitation\n of interneurons and that of principal neurons in the dentate gyrus-CA3\n network.\n                  <\/jats:p>","DOI":"10.1073\/pnas.251610898","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:07Z","timestamp":1027679707000},"page":"14708-14713","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":147,"title":["PTP and LTP at a hippocampal mossy fiber-interneuron synapse"],"prefix":"10.1073","volume":"98","author":[{"given":"Henrik","family":"Alle","sequence":"first","affiliation":[{"name":"Physiologisches Institut der Universit\u00e4t Freiburg, D-79104\r Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jonas","sequence":"additional","affiliation":[{"name":"Physiologisches Institut der Universit\u00e4t Freiburg, D-79104\r Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg R. 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