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YAP1 activation was necessary and sufficient for paligenosis-driven conversion of chief cells into metaplastic, proliferating progenitors. Additionally, we show that STK38, like canonical Hippo kinases, interacts with Neurofibromatosis Type 2 (Merlin), a scaffold that recruits Hippo kinases to phosphorylate YAP1. We also observed the same pattern of YAP1 induction via autophagic destruction of STK38 in other tissues and cell types, suggesting injury-induced activation of autophagy in differentiated cells during tissue damage may be a more general feature by which Hippo effectors induce plasticity for regeneration.<\/jats:p>","DOI":"10.1073\/pnas.2517488123","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:02:15Z","timestamp":1774897335000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Regulation of STK38 by autophagy governs YAP1 activity during paligenosis"],"prefix":"10.1073","volume":"123","author":[{"given":"Yongji","family":"Zeng","sequence":"first","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Zhe","family":"Huang","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Kay","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Johns Hopkins Medical Institutions","place":["Baltimore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6043-4287","authenticated-orcid":false,"given":"Raymond","family":"Ho","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Bark","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine","place":["Houston"]},{"name":"Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer G.","family":"Willet","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology, Washington University School of Medicine","place":["St. Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"DiPaolo","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine","place":["Saint Louis"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-4662","authenticated-orcid":false,"given":"Jason C.","family":"Mills","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine","place":["Houston"]},{"name":"Department of Pathology and Immunology, Baylor College of Medicine","place":["Houston"]},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798311"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-061121-035954"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44318-024-00099-0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.07.005"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.03.023"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.339"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.01.017"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.008"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.11.001"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI151363"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.037"},{"key":"e_1_3_4_12_2","first-page":"639","article-title":"Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma","volume":"79","author":"Schmidt P. 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