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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,12,30]]},"abstract":"<jats:p>\n                    The ability to synthesize essential molecules is sometimes lost in evolution. A classic example is ascorbate (vitamin C), which is synthesized in most animals by L-gulonolactone oxidase (GULO), an enzyme lost multiple independent times in animal evolution. This event is thought to be evolutionarily neutral; however,\n                    <jats:italic toggle=\"yes\">GULO-<\/jats:italic>\n                    deficient animals including humans need to obtain ascorbate from their diet and are prone to ascorbate deficiency and scurvy. We therefore hypothesized that this disadvantage of GULO loss is offset by physiological benefits. Here, we show that ascorbate deficiency benefits mice infected with schistosome parasites, which cause schistosomiasis, a debilitating parasitic disease that afflicts 250 million people.\n                    <jats:italic toggle=\"yes\">Schistosoma mansoni<\/jats:italic>\n                    worms required host ascorbate to produce eggs in vivo. Consequently, ascorbate-deficient mice were protected from schistosomiasis pathologies and transmission. Intermittent ascorbate deficiency protected\n                    <jats:italic toggle=\"yes\">Gulo<\/jats:italic>\n                    -deficient mice from both scurvy and schistosomiasis mortality. The effects of ascorbate on schistosome reproduction were mediated by ascorbate-dependent histone demethylation which promoted vitellocyte development in female schistosomes. We propose that vitamin deficiencies are not always detrimental but can protect animals from pathogens which need to obtain vitamins from their host.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2517730122","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:48:15Z","timestamp":1766508495000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":3,"title":["Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection"],"prefix":"10.1073","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5876-9902","authenticated-orcid":false,"given":"Gongwen","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetics and Development of Complex Phenotypes, Ministry of Education Key Laboratory of Contemporary Anthropology, Department of Microbiology and Immunology, School of Life Sciences, Fudan University","place":["Shanghai, P.R. 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